4.7 Review

Review of anticancer potentials and structure-activity relationships (SAR) of rhodanine derivatives

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Synthesis, antidiabetic activity and molecular docking study of rhodanine-substitued spirooxindole pyrrolidine derivatives as novel α-amylase inhibitors

Amani Toumi et al.

Summary: This study synthesized a series of novel rhodanine-fused spim [pyrrolidine-2,3'-oxindoles], showcasing efficient construction of diverse structures and excellent inhibition of alpha-amylase activity.

BIOORGANIC CHEMISTRY (2021)

Review Chemistry, Medicinal

The Importance of Rhodanine Scaffold in Medicinal Chemistry: A Comprehensive Overview

Arif Mermer

Summary: Rhodanine-based compounds have shown broad biological activities through various modifications to the rhodanine ring, making them important in drug discovery.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2021)

Article Chemistry, Organic

Facile synthesis of 5-arylidene rhodanine derivatives using Na2SO3 as an eco-friendly catalyst. Access to 2-mercapto-3-aryl-acrylic acids and a benzoxaborole derivative

Chaima Boureghda et al.

Summary: A simple and efficient method for synthesizing 5-arylidene rhodanines derivatives using rhodanine, various substituted aldehydes, and Na2SO3 as catalyst in ethanol has been developed. The presence of a boronic acid group is well tolerated in the transformations, allowing for the access to new benzoxaborole derivatives.

TETRAHEDRON LETTERS (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Chemistry, Medicinal

The dual inhibition against the activity and expression of tyrosine phosphatase PRL-3 from a rhodanine derivative

Lixia Lin et al.

Summary: PRL-3 is associated with metastatic potential in various cancers and compound 4 has been identified as a promising dual functional inhibitor targeting PRL-3, exhibiting anti-cancer effects by inhibiting PRL-3 activity and expression.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2021)

Article Multidisciplinary Sciences

The evolution of hematopoietic cells under cancer therapy

Oriol Pich et al.

Summary: Chemotherapies have mutational effects on secondary acute myeloid leukemia, with platinum-based drugs leaving a detectable mutational signature. The expansion of leukemia cells may begin after the initiation of therapy. Chemotherapies may increase mutagenesis in healthy cells and influence their evolution, but their exact contributions to mutation burden and clonal expansions remain unclear.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

Exploring the selectivity of guanine scaffold in anticancer drug development by computational repurposing approach

D. R. Sherin et al.

Summary: Drug repurposing is a modern technique used in drug discovery to identify new targets for existing drugs. In this study, insilico methods were used to screen FDA-approved antiviral drugs for their potential use in cancer treatment. Several guanine derivatives were found to be promising candidates for further development as anticancer drugs.

SCIENTIFIC REPORTS (2021)

Article Pharmacology & Pharmacy

Synthesis and anticancer properties of 5-(1H-benzoimidazol-2-ylmethylene)-4-oxo-2-thioxothiazolidin-3-ylcarboxilic acids

Volodymyr Horishny et al.

Summary: A series of potential anticancer compounds were synthesized and screened in vitro by NCI, showing some of them exhibited anticancer activity against specific cancer cell lines.

PHARMACIA (2021)

Review Pharmacology & Pharmacy

Drug screening of rhodanine derivatives for antibacterial activity

Suresh Maddila et al.

EXPERT OPINION ON DRUG DISCOVERY (2020)

Article Chemistry, Medicinal

Discovery of 1,3-diphenyl-1H-pyrazole derivatives containing rhodanine-3-alkanoic acid groups as potential PTP1B inhibitors

Liangpeng Sun et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2019)

Review Biotechnology & Applied Microbiology

A conceptual review of rhodanine: current applications of antiviral drugs, anticancer and antimicrobial activities

Seyyed Mojtaba Mousavi et al.

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY (2019)

Article Chemistry, Medicinal

Synthesis and biological evaluation of tryptophan-derived rhodanine derivatives as PTP1B inhibitors and anti-bacterial agents

Hongyan Liu et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Chemistry, Medicinal

Synthesis and biological evaluation of novel carbazole-rhodanine conjugates as topoisomerase II inhibitors

Hong Jiang et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2018)

Article Multidisciplinary Sciences

Rhodanine derivatives as potent anti-HIV and anti-HSV microbicides

Cristina Tintori et al.

PLOS ONE (2018)

Article Pharmacology & Pharmacy

Editorial: Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae?

Kulmira Nurgali et al.

FRONTIERS IN PHARMACOLOGY (2018)

Review Pharmacology & Pharmacy

Evolution of Cancer Pharmacological Treatments at the Turn of the Third Millennium

Luca Falzone et al.

FRONTIERS IN PHARMACOLOGY (2018)

Review Pharmacology & Pharmacy

Recent developments with rhodanine as a scaffold for drug discovery

Danylo Kaminskyy et al.

EXPERT OPINION ON DRUG DISCOVERY (2017)

Article Pharmacology & Pharmacy

Thiazolidinedione or Rhodanine: A Study on Synthesis and Anticancer Activity Comparison of Novel Thiazole Derivatives

Cigdem Ozen et al.

JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES (2017)

Article Chemistry, Multidisciplinary

Synthesis and anticancer activity of novel quinazolinone-based rhodanines

Sherihan El-Sayed et al.

CHEMISTRY CENTRAL JOURNAL (2017)

Article Biochemistry & Molecular Biology

Synthesis and in vitro evaluation of novel rhodanine derivatives as potential cholinesterase inhibitors

Martin Kratky et al.

BIOORGANIC CHEMISTRY (2016)

Article Chemistry, Medicinal

Synthesis and evaluation of some novel N-substituted rhodanines for their anticancer activity

Sulaiman Ali Muhammad et al.

MEDICINAL CHEMISTRY RESEARCH (2016)

Article Chemistry, Multidisciplinary

Novel rhodanines with anticancer activity: design, synthesis and CoMSIA study

Subhankar P. Mandal et al.

RSC ADVANCES (2016)

Article Biochemistry & Molecular Biology

Combination of 4-anilinoquinazoline and rhodanine as novel epidermal growth factor receptor tyrosine kinase inhibitors

Si-Ning Li et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2015)

Article Chemistry, Medicinal

Design, synthesis and biological evaluation of 3-aryl-rhodanine benzoic acids as anti-apoptotic protein Bcl-2 inhibitors

Huansheng Fu et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2015)

Article Chemistry, Medicinal

Rhodanine-based PRL-3 inhibitors blocked the migration and invasion of metastatic cancer cells

Garam Min et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2013)

Article Chemistry, Medicinal

2H-chromene derivatives bearing thiazolidine-2,4-dione, rhodanine or hydantoin moieties as potential anticancer agents

Mohammad Azizmohammadi et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2013)

Article Chemistry, Medicinal

Thiazolidinone-Peptide Hybrids as Dengue Virus Protease Inhibitors with Antiviral Activity in Cell Culture

Christoph Nitsche et al.

JOURNAL OF MEDICINAL CHEMISTRY (2013)

Article Biochemistry & Molecular Biology

Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 protein

Huan-qiu Li et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2012)

Article Chemistry, Medicinal

Discovery of potent and selective rhodanine type IKKβ inhibitors by hit-to-lead strategy

Hyeseung Song et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)

Article Genetics & Heredity

Gender Differences in Cancer Susceptibility: An Inadequately Addressed Issue

M. Tevfik Dorak et al.

Frontiers in Genetics (2012)

Article Biochemistry & Molecular Biology

New cholesterol esterase inhibitors based on rhodanine and thiazolidinedione scaffolds

Sabrina Heng et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2011)

Article Chemistry, Medicinal

Evaluation of dihydropyrimidin-(2H)-one analogues and rhodanine derivatives as tyrosinase inhibitors

Jinbing Liu et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2011)

Review Pharmacology & Pharmacy

Nanotherapeutics to Overcome Conventional Cancer Chemotherapy Limitations

C. Moorthi et al.

JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES (2011)

Article Chemistry, Multidisciplinary

Synthesis of a rhodanine-based compound library targeting Bcl-XL and Mcl-1

Paul H. Bernardo et al.

PURE AND APPLIED CHEMISTRY (2011)

Review Biochemistry & Molecular Biology

Rhodanine as a Privileged Scaffold in Drug Discovery

T. Tomasic et al.

CURRENT MEDICINAL CHEMISTRY (2009)

Article Chemistry, Medicinal

Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors

JH Ahn et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2006)

Article Chemistry, Medicinal

Rhodanine derivatives as inhibitors of JSP-1

NS Cutshall et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)