Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 143, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2021.112170
Keywords
MAPK; ERK pathway; Intervertebral disc degeneration (IDD); Extracellular matrix (ECM); Senescence; Apoptosis
Funding
- Special Project of the Central Government to Guide the Development of Local Science and Technology [20JR5RA129]
- Research Natural Science Founda-tion of Gansu Province [21CX1RA176]
Ask authors/readers for more resources
Intervertebral disc degeneration (IDD) is a chronic skeletal muscle degenerative disease that is considered the main cause of low back pain. It is mainly caused by aging, trauma, genetic susceptibility, and other factors. Current treatment focuses on alleviating symptoms rather than targeting pathological changes in the intervertebral discs.
Intervertebral disc degeneration (IDD) is a chronic skeletal muscle degenerative disease, which is considered the main cause of low back pain. It seriously affects the quality of life of patients and consequently brings a heavy economic burden to their families and the society. Although IDD is considered a natural process in degenerative lesions, it is mainly caused by aging, trauma, genetic susceptibility and other factors. It is closely related to changes in the tissue structure and function, including the progressive destruction of extracellular matrix, cell aging, cell death of the intervertebral disc (IVD), inflammation, and impairment of tissue biomechanical function. Currently, the treatment of IDD is aimed at alleviating symptoms rather than at targeting pathological changes in the IVD. Furthermore, the mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) signaling pathway is closely related to various pathological processes in IDD, and the activation of the MAPK/ERK pathway promotes the degradation of the IVD extracellular matrix, cell aging, apoptosis, and inflammatory responses. It also induces autophagy and oxidative stress that accelerate the IVD process. In our current review, we summarize the latest developments in the negative regulation of IDD after activation of the MAPK/ERK signaling pathway and emphasize on its influence on IDD. Targeting this pathway may become an attractive treatment strategy for IDD in the near future.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available