Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 146, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2021.112544
Keywords
miR-622; Cancer; MicroRNAs; Mechanism; Molecules
Funding
- National Natural Science Foundation of China [U20A20343]
- Independent Project Fund of the State Key Laboratory for Diagnosis and Treatment of Infectious Diseases
- Na-tional Key Research and Development Program of China [2016YFC1101404/3]
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miR-622, a type of miRNA, has been shown to influence disease progression in various tumors, including liver, colorectal, and breast cancer, as well as glioma. Studying the expression levels and mechanisms of miR-622 helps to understand its role in tumors.
Cancer is a heavy burden worldwide, with high morbidity and mortality rates. Cancer treatments currently involve surgical and nonsurgical approaches. Molecular targeted therapy is the latest breakthrough. miRNAs are small noncoding RNAs found in plants and animals that play a role in cancer and various diseases through influencing numerous biological processes, such as cell proliferation, apoptosis, the immune response, and drug resistance. One miRNA, miR-622, has been shown to regulate various pathways to influence disease processes. Abnormal miR-622 expression can promote or inhibit liver, colorectal, and breast cancers and other tumors, such as glioma. Herein, we reviewed the expression levels and clinical effects of miR-622 in various tumors and summarized its mechanisms and related molecules.
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