Journal
BIOMEDICA
Volume 41, Issue -, Pages 13-20Publisher
INST NACIONAL SALUD
DOI: 10.7705/biomedica.5662
Keywords
Bacillus clausii; bacteremia; diarrhea; probiotics; gram-positive bacteria
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This case report highlights a non-immunocompromised patient with B. clausii bacteremia after receiving probiotic treatment, urging clinicians to be cautious of potential pathogenic microorganisms post-probiotic administration to prevent systemic infection, metabolic compromise, and hemodynamic instability.
Bacillus clausii is a gram-positive rod used as a probiotic to treat diarrhea and the side effects of antibiotics such as pseudomembranous colitis. We report a case of B. clausii bacteremia in a non-immunocompromised patient with active peptic ulcer disease and acute diarrhea. The probiotic was administered during the patient ' s hospitalization due to diarrhea of infectious origin. B. clausii was identified in the bloodstream of the patient through Matrix-Assisted Laser Desorption Ionization-Time of Flight (MALDI-TOF) days after her discharge. Given the wide use of probiotics, we alert clinicians to consider this microorganism as a causative agent when signs of systemic infection, metabolic compromise, and hemodynamic instability establish after its administration and no pathogens have been identified that could explain the clinical course.
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