Journal
BIOMARKERS IN MEDICINE
Volume 16, Issue 5, Pages 349-369Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2021-0682
Keywords
cancer biomarkers; diagnosis; LINC01133; lncRNA; long non-coding RNA; prognosis
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Funding
- Department of Science and Technology, India through the Indo-Russia grant [INT/RUS/RFBR/P-311]
- DST-INSPIRE fellowship grant [IF180680]
- Indian Council of Medical Research (ICMR) [5/13/81/2013-NCD-III]
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LINC01133 has been identified as a novel transcript in cancers, playing a significant role in modulating various cancer hallmarks. It serves as both an oncogenic and tumor-suppressive factor in different types of cancers. The expression of LINC01133 is correlated with tumor characteristics and patient survival. The authors propose LINC01133 as a potential biomarker and therapeutic target in cancer.
Recently, long intergenic non-protein coding RNA 01133 (LINC01133) was identified as a novel transcript in cancers. It modulates various hallmarks of cancers and acts as oncogenic in some cancers while tumor-suppressive in others. Furthermore, the expression of LINC01133 correlates with tumor size, advanced tumor node metastasis stage and lymphatic node metastasis, Ki-67 levels and overall survival of patients. Herein, the authors provide an in-depth analysis describing how LINC01133 modulates the multiple cancer-associated signaling pathways and the pathogenesis of various malignancies and treatment regimens. Based on the role played by LINC01133, the authors propose LINC01133 as both a potential biomarker and a therapeutic target in cancer.
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