Journal
BIOMACROMOLECULES
Volume 22, Issue 11, Pages 4871-4882Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.1c01164
Keywords
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Funding
- National Natural Science Foundation [21574008, 22005020]
- Fundamental Research Funds for the Central Universities of China [BHYC1705B]
- Australian Research Council (ARC) [FT160100095]
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Amphiphilic block copolymers self-assembled into nanostructures with various morphologies through PET-RAFT polymerization, showing enhanced drug delivery efficiency.
Developing safe and efficient delivery vehicles for chemotherapeutic drugs has been a long-standing demanding. Amino acid-based polymers are promising candidates to address this challenge due to their excellent biocompatibility and biodegradation. Herein, a series of well-defined amphiphilic block copolymers were prepared by PET-RAFT polymerization of N-acryloyl amino add monomers. By altering monomer types and the block ratio of the copolymers, the copolymers self-assembled into nanostructures with various morphologies, including spheres, rod-like, fibers, and lamellae via hydrophobic and hydrogen bonding interactions. Significantly, the nanoparticles (NPs) assembled from amphiphilic block copolymers poly(N-acryloyl-valine)-b-poly(N-acryloyl-aspartic acid) (PV-b-PD) displayed an appealing cargo loading efficiency (21.8-32.6%) for a broad range of drugs (paclitaxel, doxorubicin (DOX), cisplatin, etc.) due to strong interactions. The DOX-loaded PV-b-PD NPs exhibited rapid cellular uptake (within 1 min) and a great therapeutic performance. These drug delivery systems provide new insights for regulating the controlled morphologies and improving the efficiency of drug delivery.
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