Journal
BIOLOGICAL TRACE ELEMENT RESEARCH
Volume 200, Issue 10, Pages 4238-4249Publisher
SPRINGERNATURE
DOI: 10.1007/s12011-021-03022-4
Keywords
Selenium deficiency; Arthropathies; Kashin-Beck disease; Osteoarthritis; Rheumatoid arthritis; Osteoporosis
Funding
- National Natural Science Foundation of China [81872567]
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Selenium plays a crucial role in maintaining physiological homeostasis of bone and cartilage, and its deficiency is closely associated with the pathogenesis of arthropathies.
Selenium, an essential trace element for human health, exerts an indispensable effect in maintaining physiological homeostasis and functions in the body. Selenium deficiency is associated with arthropathies, such as Kashin-Beck disease, rheumatoid arthritis, osteoarthritis, and osteoporosis. Selenium deficiency mainly affects the normal physiological state of bone and cartilage through oxidative stress reaction and immune reaction. This review aims to explore the role of selenium deficiency and its mechanisms existed in the pathogenesis of arthropathies. Meanwhile, this review also summarized various experiments to highlight the crucial functions of selenium in maintaining the homeostasis of bone and cartilage.
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