Journal
BIOLOGICAL REVIEWS
Volume 97, Issue 3, Pages 1131-1160Publisher
WILEY
DOI: 10.1111/brv.12834
Keywords
Wilhelm His; mechanobiology; evolution and development; evo-devo; gastrulation; germ layer; morphogenesis; allometry; Entwicklungsmechanik
Categories
Ask authors/readers for more resources
Wilhelm His, Sr. was the first scientist to use paraffin histology, serial sectioning, and three-dimensional modeling to study embryos. His research made significant contributions to vertebrate embryology and developmental neurobiology, and he also developed theories in mechanical and evolutionary developmental biology.
Swiss-born embryologist Wilhelm His, Sr. (1831-1904) was the first scientist to study embryos using paraffin histology, serial sectioning and three-dimensional modelling. With these techniques, His made many important discoveries in vertebrate embryology and developmental neurobiology, earning him two Nobel Prize nominations. He also developed several theories of mechanical and evolutionary developmental biology. His argued that adult form is determined by the differential growth of developmental primordia. Furthermore, he suggested that changes in the growth parameters of those primordia are responsible for generating new phenotypes during evolution. His developed these theories in his book 'Our Bodily Form' (Unsere Korperform). Here, we review His's work with special emphasis on its potential importance to the disciplines of evolutionary developmental biology (evo-devo) and mechanobiology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available