Mechanisms Underlying Recovery From Postpartum Depression Following Brexanolone Therapy

Article Neurosciences

Allopregnanolone Mediates Affective Switching Through Modulation of Oscillatory States in the Basolateral Amygdala

Pantelis Antonoudiou et al.

Summary: The study demonstrates that allopregnanolone and its neuroactive steroid analogs modulate network states in different species, with a key role in the basolateral amygdala. These steroids alter behavioral states by influencing oscillatory activities, protecting mice from chronic stress-induced disruptions in network and behavioral states.

BIOLOGICAL PSYCHIATRY (2022)

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Article Psychiatry

Neurosteroid allopregnanolone (3α,5α-THP) inhibits inflammatory signals induced by activated MyD88-dependent toll-like receptors

Irina Balan et al.

Summary: The research shows that 3 alpha, 5 alpha-THP inhibits the activation of TLR4, TLR2, and TLR7 signals, but not TLR3 signal, by blocking the TLR-MyD88 interaction. This inhibition leads to decreased production of pro-inflammatory mediators and supports the potential therapeutic use of 3 alpha, 5 alpha-THP for inflammatory diseases.

TRANSLATIONAL PSYCHIATRY (2021)

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Article Biochemistry & Molecular Biology

Peripheral inflammation is associated with micro-structural and functional connectivity changes in depression-related brain networks

Manfred G. Kitzbichler et al.

Summary: Inflammation is associated with depressive symptoms, and CRP levels are significantly related to changes in proton density and functional connectivity in the brain, particularly in DMN nodes of depressed individuals. This suggests that peripheral inflammation may mediate inflammatory effects on depression through alterations in DMN node micro-structure and connectivity.

MOLECULAR PSYCHIATRY (2021)

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Article Neurosciences