Journal
BIOINFORMATICS
Volume 38, Issue 8, Pages 2344-2347Publisher
OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btac091
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Funding
- NSF [1936791, 1919691]
- Fox Chase Cancer Center Risk Assessment Program Funds
- DOD [W81XWH-18-1-0148]
- CEP award from the Yale Head and Neck Cancer NIH SPORE
- Direct For Computer & Info Scie & Enginr
- Office of Advanced Cyberinfrastructure (OAC) [1919691] Funding Source: National Science Foundation
- Div Of Biological Infrastructure
- Direct For Biological Sciences [1936791] Funding Source: National Science Foundation
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This article introduces a user-friendly software that can aggregate and visually present results from different refitting packages for effective comparison of mutational signatures.
Motivation: The analysis of mutational signatures is becoming increasingly common in cancer genetics, with emerging implications in cancer evolution, classification, treatment decision and prognosis. Recently, several packages have been developed for mutational signature analysis, with each using different methodology and yielding significantly different results. Because of the non-trivial differences in tools' refitting results, researchers may desire to survey and compare the available tools, in order to objectively evaluate the results for their specific research question, such as which mutational signatures are prevalent in different cancer types. Results: Due to the need for effective comparison of refitting mutational signatures, we introduce a user-friendly software that can aggregate and visually present results from different refitting packages.
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