4.7 Article

Oligodeoxynucleotides Modified with 2′-O-(Cysteinylaminobutyl)carbamoylethylribothymidine Residues for Native Chemical Ligation with Peptide at Internal Positions

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Evaluation of Phosphorus and Non-Phosphorus Neutral Oligonucleotide Backbones for Enhancing Therapeutic Index of Gapmer Antisense Oligonucleotides

Guillermo Vasquez et al.

Summary: The phosphorothioate (PS) linkage plays a crucial role in therapeutic oligonucleotides by enhancing therapeutic index. The exploration of phosphorus- and non-phosphorus-based neutral backbone modifications can improve the activity of neutral linkages, but factors such as chemical stability and properties need to be considered.

NUCLEIC ACID THERAPEUTICS (2022)

Article Chemistry, Medicinal

Synthesis of 2′-O-alkylcarbamoylethyl-modified oligonucleotides with enhanced nuclease resistance that form isostable duplexes with complementary RNA

Tomohiro Kishimura et al.

Summary: A variety of 2'-O-alkylcarbamoyl-ethyl modified oligonucleotides were synthesized, showing improved duplex stability and resistance to 3'-exonuclease. These modifications have been proven useful for various biological applications.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2021)

Article Biochemistry & Molecular Biology

Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides

Brooke A. Anderson et al.

Summary: The study found that replacing PS linkages with MsPA in Gapmer ASOs can improve nuclease stability, reduce immune stimulation and cytotoxicity, and extend the duration of ASO action in mice.

NUCLEIC ACIDS RESEARCH (2021)

Review Biochemical Research Methods

Postsynthetic Modifications of DNA and RNA by Means of Copper-Free Cycloadditions as Bioorthogonal Reactions

Katja Krell et al.

BIOCONJUGATE CHEMISTRY (2020)

Review Biotechnology & Applied Microbiology

Advances in oligonucleotide drug delivery

Thomas C. Roberts et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Review Chemistry, Multidisciplinary

Native Chemical Ligation and Extended Methods: Mechanisms, Catalysis, Scope, and Limitations

Vangelis Agouridas et al.

CHEMICAL REVIEWS (2019)

Article Chemistry, Organic

Stereocontrolled Synthesis of Boranophosphate DNA by an Oxazaphospholidine Approach and Evaluation of Its Properties

Rintaro Iwata Hara et al.

JOURNAL OF ORGANIC CHEMISTRY (2019)

Article Chemistry, Organic

A 2′,2′-disulfide-bridged dinucleotide conformationally locks RNA hairpins

Florian Gauthier et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2018)

Review Biochemistry & Molecular Biology

Cell-Penetrating Peptides to Enhance Delivery of Oligonucleotide-Based Therapeutics

Graham McClorey et al.

BIOMEDICINES (2018)

Article Chemistry, Multidisciplinary

Rapid Formation of a Supramolecular Polypeptide-DNA Hydrogel for In Situ Three-Dimensional Multilayer Bioprinting

Chuang Li et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

Article Chemistry, Organic

Probing heterobivalent binding to the endocytic AP-2 adaptor complex by DNA-based spatial screening

F. Diezmann et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2015)

Review Chemistry, Multidisciplinary

Click reactions: a versatile toolbox for the synthesis of peptide-conjugates

Wen Tang et al.

CHEMICAL SOCIETY REVIEWS (2014)

Article Chemistry, Multidisciplinary

DNA as a Molecular Ruler: Interrogation of a Tandem SH2 Domain with Self-Assembled, Bivalent DNA-Peptide Complexes

Hendrik Eberhard et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)

Review Chemistry, Multidisciplinary

DNA-guided display of proteins and protein ligands for the interrogation of biology

Franziska Diezmann et al.

CHEMICAL SOCIETY REVIEWS (2011)

Article Chemistry, Multidisciplinary

Native Chemical Ligation of Hydrolysis-Resistant 3′-Peptidyl-tRNA Mimics

Anna-Skrollan Geiermann et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)

Article Biochemistry & Molecular Biology

Native Chemical Ligation in the Synthesis of Internally Modified Oligonucleotide-Peptide Conjugates

Franziska Diezmann et al.

BIOPOLYMERS (2010)

Article Chemistry, Multidisciplinary

Creating Protein Affinity Reagents by Combining Peptide Ligands on Synthetic DNA Scaffolds

Berea A. R. Williams et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2009)

Review Chemistry, Multidisciplinary

Peptide conjugates of oligonucleotides: Synthesis and applications

Natarajan Venkatesan et al.

CHEMICAL REVIEWS (2006)

Article Chemistry, Medicinal

Synthesis of oligonucleotide 2′-conjugates via amide bond formation in solution

AV Kachalova et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)

Article Chemistry, Multidisciplinary

Solid-phase chemical synthesis of phosphonoacetate and thiophosphonoacetate oligodeoxynucleotides

DJ Dellinger et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)

Article Biochemistry & Molecular Biology

Control of intracellular delivery of oligonucleotides by conjugation with signal peptides

M Yano et al.

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2003)

Article Chemistry, Organic

Efficient conjugation of peptides to oligonucleotides by native ligation

DA Stetsenko et al.

JOURNAL OF ORGANIC CHEMISTRY (2000)