Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume 1866, Issue 11, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.bbalip.2021.159020
Keywords
Intrinsic disorder; Intrinsically disordered protein; Lipid transport; OSBP; Membrane tethering; Membrane contact site; Lateral diffusion; VAP
Funding
- labex Signalife PhD program [ANR-11-LABX-0028-01]
Ask authors/readers for more resources
Membrane contact sites are regions of close apposition between membrane-bound organelles, where proteins, including lipid transfer proteins, display various domain organization. Intrinsic disordered protein regions play multiple roles in LTPs, such as serving as flexible tethers between membranes, entropic barriers, and defining the action range of catalytic domains. These functions, along with mediating protein-protein and protein-membrane interactions, require fine coordination for the efficiency and fidelity of contact sites.
Membrane contact sites (MCS) are regions of close apposition between membrane-bound organelles. Proteins that occupy MCS display various domain organisation. Among them, lipid transfer proteins (LTPs) frequently contain both structured domains as well as regions of intrinsic disorder. In this review, we discuss the various roles of intrinsically disordered protein regions (IDPRs) in LTPs as well as in other proteins that are associated with organelle contact sites. We distinguish the following functions: (i) to act as flexible tethers between two membranes; (ii) to act as entropic barriers to prevent protein crowding and regulate membrane tethering geometry; (iii) to define the action range of catalytic domains. These functions are added to other functions of IDPRs in membrane environments, such as mediating protein-protein and protein-membrane interactions. We suggest that the overall efficiency and fidelity of contact sites might require fine coordination between all these IDPR activities.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available