Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 583, Issue -, Pages 146-153Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2021.10.066
Keywords
Acacetin; RANKL; NFATc1; Osteoclast; Osteolysis
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Funding
- Application of Public Welfare Technology in Zhejiang Province [LGF21H060001]
- Medical and Health Science and Technology Project of Zhejiang Province [2021KY1086]
- Traditional Chinese Medicine Scientific Research and Technology Project of Zhejiang Province [2021ZB280]
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This study demonstrated for the first time that acacetin inhibited osteoclastogenesis, bone resorption activity, and related gene expression by modulating multiple signaling pathways, suggesting its potential therapeutic effects for preventing osteoporosis and other osteolytic disorders.
Osteolytic disorders are characterized by impaired bone volume and trabecular structure that leads to severe fragility fractures. Studies have shown that excessive osteoclast activity causes impaired bone microstructure, a sign of osteolytic diseases such as osteoporosis. Approaches of inhibiting osteoclastogenesis and bone resorption specifically could prevent osteoporosis and other osteolytic disorders. Acacetin is a potent molecule extracted from plants with anti-cancer and anti-inflammatory bioactivities. Here, we demonstrated, for the first time, that acacetin repressed osteoclastogenesis, formation of F-actin rings, bone resorption activity, and osteoclast-related gene expression in vitro through modulating ERK, P38, and NF -KB signaling pathways and preventing expression of NFATc1. Micro-CT and H & E staining results indicated that acacetin alleviated LPS-induced osteolysis in vivo. Overall, our findings suggested that acacetin could help to prevent osteoporosis and other osteoclast-related osteolytic disorders. (c) 2021 Elsevier Inc. All rights reserved.
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