Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 587, Issue -, Pages 58-62Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2021.11.093
Keywords
Alzheimer's disease; Neural circuits; Radiotracers; Tau aggregates; Diagnosis
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Funding
- Department of Biotechnology, India (Department of Biotechnology Genomics Engineering Taskforce)
- DBT-IISc Partnership program IISC-STAR program grant
- Council of Scientific and Industrial Research, India
- Science and En-gineering Research Board (SERB) , New Delhi, India [CRG/2018/002084]
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Advancements in brain imaging techniques, especially with Positron emission tomography (PET), have become a significant tool in detecting Alzheimer's disease progression. The focus on investigational PET tracers targeting neurofibrillary tau aggregates found typically in AD is highlighted in this review. The discussion of the importance of several PET radiotracers and challenges in PET imaging is also emphasized.
Advancements in brain imaging techniques have emerged as a significant tool in detecting Alzheimer's disease (AD) progression. The complicated cascade of AD progression can be detected using radio imaging, especially with Positron emission tomography (PET). The review focus on recently introduced investigational PET tracers targeting neurofibrillary tau aggregates found typically in AD. Herein, we also address the use of different PET tracers and the clinical implementation of established and newer generation tracers. This review also intends to discuss the importance of several PET radiotracers and challenges in PET imaging. (c) 2021 Elsevier Inc. All rights reserved.
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