4.6 Article

Covalent inhibition of P. falciparum ferredoxin-NADP plus reductase: Exploring alternative strategies for the development of new antimalarial drugs

Related references

Note: Only part of the references are listed.
Review Cell Biology

Transforming nanobodies into high-precision tools for protein function analysis

Jan Gettemans et al.

Summary: Single-domain antibodies derived from camelids and sharks, known as nanobodies, have gained attention for their high specificity and affinity binding to targets. Their key features including single-domain nature, small size, affordable high-level expression, and flexibility in altering primary structure have made them appealing for researchers and valuable in biomedical research.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2021)

Article Infectious Diseases

Global Tuberculosis Report 2020-Reflections on the Global TB burden, treatment and prevention efforts

Jeremiah Chakaya et al.

Summary: The global TB report for October 2020 highlights slow progress in TB control efforts and the need to ramp up screening and diagnostic test services. Key drivers of TB, including undernutrition, poverty, diabetes, tobacco smoking, and household air pollution, must be addressed to achieve WHO 2035 TB care and prevention targets. Global focus is needed on the development of new vaccines for TB using new technological methods.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

Article Chemistry, Multidisciplinary

A Class of Valuable (Pro-)Activity-Based Protein Profiling Probes: Application to the Redox-Active Antiplasmodial Agent, Plasmodione

Bogdan Adam Cichocki et al.

Summary: Plasmodione (PD) is a potent antimalarial drug that acts on different malaria parasite stages at low concentrations. Through the development of a novel class of (pro-)activity-based protein profiling probes, this study identified the precise protein interactome of PD in parasites. The synthesized photoreactive and clickable probes proved to be valuable for exploring the mode of action of antimalarial drugs.

JACS AU (2021)

Article Biochemistry & Molecular Biology

Reactions of Plasmodium falciparum Ferredoxin:NADP+ Oxidoreductase with Redox Cycling Xenobiotics: A Mechanistic Study

Mindaugas Lesanavicius et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Biochemistry & Molecular Biology

Covalent inhibitors: a rational approach to drug discovery

Fandi Sutanto et al.

RSC MEDICINAL CHEMISTRY (2020)

Article Biochemistry & Molecular Biology

Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene

Audrey R. Odom et al.

MOLECULAR AND BIOCHEMICAL PARASITOLOGY (2010)

Article Biochemistry & Molecular Biology

The ferredoxin-NADP+ reductase/ferredoxin electron transfer system of Plasmodium falciparum

Emanuela Balconi et al.

FEBS JOURNAL (2009)

Article Biochemistry & Molecular Biology

Structural and functional diversity of ferredoxin-NADP+ reductases

Alessandro Aliverti et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2008)

Article Biochemistry & Molecular Biology

The structural and functional studies of His119 and His12 in RNase A via chemical modification

S Safarian et al.

JOURNAL OF PROTEIN CHEMISTRY (2003)