Organocatalytic asymmetric nitroso aldol reaction of α-substituted malonamates

A practical enantioselective N-selective nitroso aldol reaction of alpha-methylmalonamates with a nitrosoarene is reported. The reaction employs the Takemoto thiourea catalyst for the induction of enantioselectivity, and the corresponding optically active oxyaminated malonamates were obtained in reasonably good yields.

Automated summary

The practical enantioselective N-selective nitroso aldol reaction of alpha-methylmalonamates with a nitrosoarene is reported. The Takemoto thiourea catalyst was employed to induce enantioselectivity, leading to the formation of optically active oxyaminated malonamates in reasonably good yields.