Journal
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
Volume 17, Issue -, Pages 2488-2495Publisher
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.17.165
Keywords
amination; C-H activation; copper; ferrocene; mono-selectivity
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Funding
- National Natural Science Foundation of China [21925109, 21772170]
- China Postdoctoral Science Foundation [2021M692771]
- Center of Chemistry for Frontier Technologies of Zhejiang University
- Open Research Fund of School of Chemistry and Chemical Engi-neering of Henan Normal University
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In this study, a copper-catalyzed mono-selective C-H amination of ferrocenes assisted by 8-aminoquinoline was successfully demonstrated, allowing for efficient installation of a range of amines to the ortho-position of ferrocene amides under mild conditions. The gram-scale reaction proceeded smoothly, and the directing group could be easily removed under basic conditions.
A copper-catalyzed mono-selective C-H amination of ferrocenes assisted by 8-aminoquinoline is presented here. A range of amines, including bioactive molecules, were successfully installed to the ortho-position of ferrocene amides with high efficiency under mild conditions. A range of functionalized ferrocenes were compatible to give the aminated products in moderate to good yields. The gram-scale reaction was smoothly conducted and the directing group could be removed easily under basic conditions.
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