Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 416, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.bbr.2021.113558
Keywords
Maternal care; Prenatal stress; Perinatal behavior; Drug development; Chronic stress
Categories
Funding
- Brockman Foundation
- Elizabeth Ring Mather & William Gwinn Mather Fund
- S. Livingston Samuel Mather Trust
- G.R. Lincoln Family Foundation
- Wick Foundation
- Leonard Krieger Fund of the Cleveland Foundation
- Maxine and Lester Stoller Parkinson's Research Fund
- Louis Stokes VA Medical Center
- Allen Initiative in Brain Health and Cognitive Impairment [19PABH134580006-AHA]
- Roy J. Carver Charitable Trust
- Nellie Ball Trust
- NIH [R01 MH122485-01]
- University of Iowa Environmental Health Science Research Center [P30 ES005605]
- University of Iowa Graduate Post-Comprehensive Research Fellowship
- Ballard-Seashore Dissertation Fellowship
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Chronic gestational stress can lead to aberrant maternal care behavior and abnormal weight gain in dams, but treatment with the NAD+ stabilizer P7C3-A20 can partially mitigate these effects, highlighting the need for further research on the impact of chronic gestational stress on maternal care behavior.
Chronic stress during pregnancy harms both the mother and developing child, and there is an urgent unmet need to understand this process in order to develop protective treatments. Here, we report that chronic gestational stress (CGS) causes aberrant maternal care behavior in the form of increased licking and grooming, decreased nursing, and increased time spent nest building. Treatment of CGS-exposed dams with the NAD+-stabilizing agent P7C3-A20 during pregnancy and postpartum, however, preserved normal maternal care behavior. CGS also caused abnormally low weight gain during gestation and postpartum, which was partially ameliorated by maternal treatment with P7C3-A20. Dams also displayed hyperactive locomotion after CGS, which was not affected by P7C3-A20. Although dams did not display a classic depressive-like phenotype after CGS, some changes in anxiety- and depressive-like behaviors were observed. Our results highlight the need for further characterization of the effects of chronic gestational stress on maternal care behavior and provide clues to possible protective mechanisms.
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