Journal
ATMOSPHERIC ENVIRONMENT
Volume 264, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.atmosenv.2021.118668
Keywords
Air pollution; Parkinson's disease; Exacerbation; Morbidity
Funding
- Sante publique France
- French National Public Health Agency
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Recent research suggests a significant short-term association between PM10, PM2.5, and NO2 and hospital admissions for Parkinson's disease, while the influence of ozone is smaller but still present. This indicates that air pollutants may have an impact on the occurrence of PD.
Background: Recent studies have investigated the potential neurological impacts of short-term exposure to air pollutants, but with limited evidence. Objective: To analyze the relationship and quantify the short-term association of air pollution (PM10, PM2.5, NO2 and ozone) and hospital admissions for Parkinson's disease (PD), in 18 French areas. Methods: We modeled the daily number of PD-related hospital admissions in each area using a generalized additive Poisson regression model for the 2009-2017 period, introducing air pollutants as the main environmental variable and daily temperature as covariate. We controlled for long-term trend and seasonality. Results: A small but significant influence of PM10, PM2.5 and NO2 on all-ages PD hospital admissions was observed, of a similar order of magnitude (1.010 [95% CI: 1.004; 1.016], 1.010 [1.003; 1.017], and 1.011 [1.005; 1.016] for a 10 mu g/m(3) increase in PM10, PM2.5 and NO2, respectively). We also found an increase in hospitalization risks, at the limit of significance, associated with ozone (1.001 [95% CI: 0.999; 1.004]). Conclusion: Our results suggest a short-term association between PM, NO2, ozone and daily hospital admissions due to PD.
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