4.6 Article

Cholesterol uptake capacity: A new measure of high-density lipoprotein functionality as a predictor of subsequent revascularization in patients undergoing percutaneous coronary intervention

Journal

ATHEROSCLEROSIS
Volume 345, Issue -, Pages 44-50

Publisher

ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2022.01.014

Keywords

High-density lipoprotein; Functionality of high-density lipoprotein; Cholesterol efflux capacity; Cholesterol uptake capacity; Coronary artery disease; Secondary prevention

Funding

  1. Sysmex Corporation

Ask authors/readers for more resources

This study evaluated the association between cholesterol-uptake capacity (CUC) of high-density lipoprotein (HDL) and revascularization after percutaneous coronary intervention (PCI). The results showed that the serum CUC level at the index PCI was independently associated with subsequent revascularization. Continuous assessment of HDL functionality by CUC might help predict revascularization after PCI.
Background and aims: High-density lipoprotein (HDL) functionality is an important determinant of coronary artery disease (CAD) development. We recently developed cholesterol-uptake capacity (CUC), a rapid cell-free assay system that directly evaluates the capacity of HDL to accept additional cholesterol. We aimed to evaluate the association between CUC and revascularization in patients who have undergone percutaneous coronary intervention (PCI). Methods: We retrospectively reviewed patients who underwent PCI with subsequent revascularization or coronary angiography (CAG) without revascularization. The patients who had frozen blood samples for which CUC were measurable at the index PCI and follow-up were enrolled. Results: We finally enrolled 74 patients who underwent subsequent revascularization and 183 patients who underwent follow-up CAG without revascularization. The serum CUC level at the index PCI was significantly lower in the revascularization group than that in the non-revascularization group (84.3 [75.2-98.9] vs. 92.0 [81.6-103.3 A U.]; p = 0.004). Multivariate logistic regression analysis revealed that decreased serum CUC level at the index PCI was independently associated with subsequent revascularization (odds ratio, 0.98; 95% confidence interval, 0.969-1.000). After adjusting for 16 cardiovascular risk factors, the serum CUC level at the index PCI and follow-up and the absolute change in serum CUC level from the index PCI to follow-up were significantly lower in the revascularization group than those in the non-revascularization group. Conclusions: Serum CUC level at index PCI was independently associated with subsequent revascularization after PCI. Continuous assessment of HDL functionality by CUC might help predict subsequent revascularization after PCI.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available