Journal
ARCHIVES OF VIROLOGY
Volume 167, Issue 2, Pages 563-570Publisher
SPRINGER WIEN
DOI: 10.1007/s00705-021-05317-2
Keywords
-
Categories
Funding
- Lund University
- Swedish Research Council-Medicine [VR2019-01210]
- Swedish Cancer Society [CAN2018/702]
- China Scholarship Council [201706170061, 201607930006, 201809120016, 201606525004]
Ask authors/readers for more resources
The majority of SR proteins and hnRNPs have the potential to regulate HPV16 L1 mRNA splicing, with specific proteins having the ability to induce HPV16 late gene expression effectively, potentially contributing to the persistence of HPV16.
We have determined the effect of seven serine- and arginine-rich (SR) proteins and 15 heterogenous nuclear ribonucleoproteins (hnRNPs) on human papillomavirus type 16 (HPV16) late gene expression. Of the seven SR proteins analyzed here, SRSF1, SRSF3, and SRSF9 induced HPV16 late gene expression, and five of the SR proteins affected HPV16 L1 mRNA splicing. Of the 15 hnRNP proteins analyzed here, hnRNP A2, hnRNP F, and hnRNP H efficiently induced HPV16 late gene expression, and all of the hnRNPs affected HPV16 L1 mRNA levels or mRNA splicing. Thus, the majority of SR proteins and hnRNPs have the potential to regulate HPV16 L1 mRNA splicing. Strict control of the expression of the immunogenic L1 and L2 capsid proteins may contribute to the ability of HPV16 to cause persistence.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available