Journal
ARCHIVES OF GERONTOLOGY AND GERIATRICS
Volume 98, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.archger.2021.104559
Keywords
Older adults; Lifestyle; Aging; Mortality; Mediation analysis
Categories
Funding
- National Natural Science Foundation of China [82171584]
- 2020 Milstein Medical Asian American Partnership Foundation Irma and Paul Milstein Program for Senior Health project award
- Fundamental Research Funds for the Central Universities
- National Social Science Foundation of China [20BGL275]
- U.S. National Institutes on Aging [R01AG023627]
- China National Natural Science Foundation [71233001, 71110107025]
- China Social Science Foundation
- UNFPA
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The study found that in the older Chinese population, a healthy lifestyle decreases the risk of mortality, with aging partially mediating this association.
Objectives: 1) examine the association between lifestyle and mortality; 2) examine the association between two aging measures and mortality; 3) evaluate the mediating effect of the two aging measures on the association between lifestyle and mortality among older Chinese adults. Methods: We used data from 2039 older adults (>= 65 years) from the 2011/2012 biomarker substudy of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). We created a healthy lifestyle index based on 5 factors (exercise, smoking, drinking, diet, and BMI, range: 0-5). We calculated two aging measures, the Klemera and Doubal method-biological age (KDM-BA) and physiological dysregulation (PD), based on 10 blood-based bio-markers using algorithms developed previously. A Cox proportional hazards model, general linear regression model, and formal mediation analysis were performed. Results: After adjustment for age and sex, compared to participants without any healthy lifestyle factors, those with 5 healthy lifestyle factors had an 85% lower risk of mortality (hazard ratio [HR] = 0.15, 95% confidence interval [CI]: 0.04, 0.60). PD, but not KDM-BA, was significantly associated with mortality (HR = 1.69, 95% CI: 1.25, 2.29). The healthy lifestyle index was negatively associated with PD (beta =-0.021, P = 0.012). PD mediated 9% (95% CI: 1%, 52%, P = 0.043) of the total effect of the healthy lifestyle index on mortality. Conclusions: In the older Chinese population, healthy lifestyle reduces mortality risk and aging partially mediates this association. The findings highlight the importance of adherence to a healthy lifestyle for promoting phenotypic aging even in late life.
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