Journal
ARCHIVES OF DISEASE IN CHILDHOOD
Volume 107, Issue 9, Pages 784-789Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/archdischild-2020-320875
Keywords
microbiology; gastroenterology
Categories
Ask authors/readers for more resources
This review examines the role of the gut microbiome in pediatric gut diseases and finds limited implications for unraveling disease pathogenesis or guiding clinical practice. In the future, the gut microbiome may be used for disease differential diagnosis and prediction of clinical outcomes, as well as a target for therapeutic interventions.
In the human gut resides a vast community of microorganisms which perform critical functions for the maintenance of whole body homeostasis. Changes in the composition and function of this community, termed microbiome, are believed to provoke disease onset, including non-communicable diseases. In this review, we debate the current evidence on the role of the gut microbiome in the pathogenesis, outcomes and management of paediatric gut disease. We conclude that even though the gut microbiome is altered in paediatric inflammatory bowel disease, coeliac disease, intestinal failure, necrotising enterocolitis and irritable bowel syndrome, there are currently very few implications for unravelling disease pathogenesis or guiding clinical practice. In the future, the gut microbiome may aid in disease differential diagnosis and prediction of clinical outcomes, and comprise a target for therapeutic interventions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available