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Almas Siddiqui et al.
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SIRT1 Protects against α-Synuclein Aggregation by Activating Molecular Chaperones
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NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)
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Kim J. Krishnan et al.
NEUROBIOLOGY OF AGING (2012)
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Brian R. Berquist et al.
NUCLEIC ACIDS RESEARCH (2012)
Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans
Amanda S. Bess et al.
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PGC-1α Rescues Huntington's Disease Proteotoxicity by Preventing Oxidative Stress and Promoting TFEB Function
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The Logic Linking Protein Acetylation and Metabolism
Leonard Guarente
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Brain Energy Metabolism: Focus on Astrocyte-Neuron Metabolic Cooperation
Mireille Belanger et al.
CELL METABOLISM (2011)
ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair
Claudia Cosentino et al.
EMBO JOURNAL (2011)
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Maria Manczak et al.
HUMAN MOLECULAR GENETICS (2011)
Parkin Ubiquitinates Drp1 for Proteasome-dependent Degradation IMPLICATION OF DYSREGULATED MITOCHONDRIAL DYNAMICS IN PARKINSON DISEASE
Hongxia Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
In Vitro and in Vivo Aggregation of a Fragment of Huntingtin Protein Directly Causes Free Radical Production
Sarah Hands et al.
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Huntington's disease: from molecular pathogenesis to clinical treatment
Christopher A. Ross et al.
LANCET NEUROLOGY (2011)
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NATURE MEDICINE (2011)
Nuclear localization sequence of FUS and induction of stress granules by ALS mutants
Jozsef Gal et al.
NEUROBIOLOGY OF AGING (2011)
Aprataxin localizes to mitochondria and preserves mitochondrial function
Peter Sykora et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
DNA repair deficiency in neurodegeneration
Dennis Kjolhede Jeppesen et al.
PROGRESS IN NEUROBIOLOGY (2011)
Discovery of the Negative Regulator of Nrf2, Keap1: A Historical Overview
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Bo Su et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2010)
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Maria D. Aamann et al.
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FREE RADICAL BIOLOGY AND MEDICINE (2010)
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Yasushi Enokido et al.
JOURNAL OF CELL BIOLOGY (2010)
Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging
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JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Loss of autophagy in erythroid cells leads to defective removal of mitochondria and severe anemia in vivo
M. Mortensen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Role of tyrosyl-DNA phosphodiesterase (TDP1) in mitochondria
Benu Brata Das et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
The Many Functions of APE1/Ref-1: Not Only a DNA Repair Enzyme
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Pia O. Osenbroch et al.
FEBS JOURNAL (2009)
Effects of overexpression of Huntingtin proteins on mitochondrial integrity
Hongmin Wang et al.
HUMAN MOLECULAR GENETICS (2009)
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Janelle L. Harris et al.
HUMAN MOLECULAR GENETICS (2009)
Cockayne Syndrome Group B Protein Stimulates Repair of Formamidopyrimidines by NEIL1 DNA Glycosylase
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Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease
Xinglong Wang et al.
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Defective DNA Ligation during Short-Patch Single-Strand Break Repair in Ataxia Oculomotor Apraxia 1
John J. Reynolds et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1
Angel Herrero-Mendez et al.
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Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity
James E. Cleaver et al.
NATURE REVIEWS GENETICS (2009)
Oxidative stress induces degradation of mitochondrial DNA
Inna Shokolenko et al.
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S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury
Dong-Hyung Cho et al.
SCIENCE (2009)
Identification and characterization of FUS/TLS as a new target of ATM
Mary Gardiner et al.
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C. A. Davie
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Karine Sii-Felice et al.
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Michelangelo Mancuso et al.
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8,5′-Cyclopurine-2′-deoxynucleosides in DNA:: Mechanisms of formation, measurement, repair and biological effects
Pawel Jaruga et al.
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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Gilad Twig et al.
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A FRET-based method to study protein thiol oxidation in histological preparations
Pier G. Mastroberardino et al.
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Long patch base excision repair in mammalian mitochondrial Genomes
Bartosz Szczesny et al.
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Transcription-coupled DNA repair: two decades of progress and surprises
Philip C. Hanawalt et al.
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Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
Xinglong Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cells
Mark Ambrose et al.
HUMAN MOLECULAR GENETICS (2007)
Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis
Jana S. Eaton et al.
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Lior Weissman et al.
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SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis
Dohoon Kim et al.
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M. D'Errico et al.
ONCOGENE (2007)
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Tetsuro Murakami et al.
BRAIN RESEARCH (2007)
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
Shuhei Matsuoka et al.
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OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells
Irina V. Kovtun et al.
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Mary Ann Osley et al.
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Frederic Coin et al.
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Hagit B. Suliman et al.
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Constitutive expression and cytoplasmic compartmentalization of ATM protein in differentiated human neuron-like SH-SY5Y cells
Jessica K. Boehrs et al.
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Cockayne syndrome B protein stimulates apurinic endonuclease 1 activity and protects against agents that introduce base excision repair intermediates
Heng-Kuan Wong et al.
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Base damage and single-strand break repair: Mechanisms and functional significance of short- and long-patch repair subpathways
Paola Fortini et al.
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Laura J. Niedernhofer et al.
NATURE (2006)
Spy1 expression prevents normal cellular responses to DNA damage - Inhibition of apoptosis and checkpoint activation
Randy F. Gastwirt et al.
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Defective mitochondrial peroxiredoxin-3 results in sensitivity to oxidative stress in Fanconi anemia
Sudit S. Mukhopadhyay et al.
JOURNAL OF CELL BIOLOGY (2006)
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
Michael T. Lin et al.
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Transcriptional repression of PGC-α by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration
Libin Cui et al.
CELL (2006)
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Takeo Arai et al.
ACTA NEUROPATHOLOGICA (2006)
Cockayne syndrome group B protein (CSB) plays a general role in chromatin maintenance and remodeling
John C. Newman et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
A Bender et al.
NATURE GENETICS (2006)
Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons
Y Kraytsberg et al.
NATURE GENETICS (2006)
Genetic effects of oxidative DNA damages: comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells
M. Abul Kalam et al.
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Cholesterol as a risk factor for Alzheimer's disease - epidemiological evidence
M. Kivipelto et al.
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ATP-dependent chromatin remodeling and DNA double-strand break repair
H van Attikum et al.
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J Fukae et al.
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SF El-Khamisy et al.
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Oxidative nucleotide damage and superoxide dismutase expression in the brains of xeroderma pigmentosum group A and Cockayne syndrome
M Hayashi et al.
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Reactive oxygen species derived from the mitochondrial respiratory chain are not responsible for the basal levels of oxidative base modifications observed in nuclear DNA of mammalian cells
S Hoffmann et al.
FREE RADICAL BIOLOGY AND MEDICINE (2004)
DNA single-strand breaks and neurodegeneration
KW Caldecott
DNA REPAIR (2004)
Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication
PE Coskun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Premature ageing in mice expressing defective mitochondrial DNA polymerase
A Trifunovic et al.
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Aprataxin, a novel protein that protects against genotoxic stress
N Gueven et al.
HUMAN MOLECULAR GENETICS (2004)
8-Oxoguanine DNA damage: at the crossroad of alternative repair pathways
P Fortini et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2003)
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T Uziel et al.
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MS Cooke et al.
FASEB JOURNAL (2003)
Molecular views of recombination proteins and their control
SC West
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CSB is a component of RNA pol I transcription
J Bradsher et al.
MOLECULAR CELL (2002)
Mutation of TDP1, encoding a topoisomerase I-dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy
H Takashima et al.
NATURE GENETICS (2002)
Mitochondrial DNA deletions/rearrangements in Parkinson disease and related neurodegenerative disorders
GY Gu et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2002)
Elevated oxidative stress in patients with ataxia telangiectasia
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Impairment of mitochondrial DNA repair enzymes against accumulation of 8-oxo-guanine in the spinal motor neurons of amyotrophic lateral sclerosis
H Kikuchi et al.
ACTA NEUROPATHOLOGICA (2002)
High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain
MT Lin et al.
HUMAN MOLECULAR GENETICS (2002)
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MC Moreira et al.
NATURE GENETICS (2001)
The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis
S Frank et al.
DEVELOPMENTAL CELL (2001)
Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene
H Date et al.
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The mitochondrial permeability transition initiates autophagy in rat hepatocytes
SP Elmore et al.
FASEB JOURNAL (2001)
Mitochondrial DNA deletion mutation levels are elevated in ALS brains
GK Dhaliwal et al.
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JE Cleaver
JOURNAL OF DERMATOLOGICAL SCIENCE (2000)