Journal
AQUACULTURE
Volume 548, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.aquaculture.2021.737708
Keywords
Penaeus vannamei; Ftz-F1; White spot syndrome virus; Dorsal; Cactus
Categories
Funding
- National Natural Science Foundation of China [31772881, 31972823, 32073004]
- Natural Science Foundation of Guangdong Province, China [2020A1515011152, 2021A1515010539]
- National Key Research and Development Program of China [2018YFD0900505]
- Science and Technology Planning Project of Guangdong Province of China [2018A050506027]
- China Agriculture Research System [CARS48]
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The NF-KB signaling pathway plays a crucial role in the immune response of shrimp, while Ftz-F1H is involved in antiviral response, promoting WSSV infection by inhibiting the activation of the Dorsal pathway.
White spot syndrome virus (WSSV) is currently a major viral pathogen of cultured shrimp. The NF-KB signaling is central to the regulation of immune responses in both invertebrates and vertebrates. Dorsal is a member of the NF-KB family in arthropods, playing important role in shrimp antiviral response. The fushi tarazu (FTZ) transcription factor (Ftz-F1) homologue (Ftz-F1H) is a novel identified orphan nuclear receptor in Pacific white shrimp Penaeus vannamei with an inhibitory effect on anti-Vibrio parahaemolyticus response. The current study investigated the role of Ftz-F1H in the immune response against WSSV infection. We showed that Ftz-F1H directly promoted the expression of Cactus, the cytoplasmic inhibitor of the Dorsal pathway in shrimp, and inhibited the nuclear translocation of Dorsal. Silencing of Ftz-F1H in vivo suppressed the WSSV infection in shrimp. These suggested that Ftz-F1H could promote WSSV infection by inhibiting the activation of the Dorsal pathway. This study, together with the previous finding, indicated that inhibition of Ftz-F1H in shrimp could enhance the defense against both bacterial and viral infections.
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