Journal
APPLIED RADIATION AND ISOTOPES
Volume 180, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.apradiso.2021.110032
Keywords
Fluorine-18; F-18; Positron emission tomography; Radiosynthesis; Radiochemistry; Automation
Categories
Funding
- National Institute of Biomedical Imaging and Bioengineering [R01EB028338-01]
- University of Virginia BRAIN Institute [LC00183]
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An automated radiosynthesis method for [F-18]DPA-714 was developed on a commercially available platform, complying with USP guidelines and facilitating dissemination. This will aid in the research of TSPO-related pathology.
[F-18]DPA-714 is a radiotracer specific to the translocator protein (TSPO) and is useful for in vivo Positron Emission Tomography imaging studies. In this report, we have developed an automated radiosynthesis of [F-18] DPA-714 on a commercially-available radiosynthesis platform, which comports with USP <823> guidelines. The wide availability of the radiosynthesis module and ease of dissemination of the production sequence will facilitate preclinical and clinical research of TSPO-related pathology.
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