Journal
APPLIED ORGANOMETALLIC CHEMISTRY
Volume -, Issue -, Pages -Publisher
WILEY
DOI: 10.1002/aoc.6645
Keywords
anticancer activity; disproportionation; gold; ligand exchange; N-heterocyclic carbene; thiocarboxylate ligands
Categories
Funding
- European Union Horizon 2020 research project and innovation program under the Marie Sklodowska-Curie Grant [872370]
- Curtin Faculty ORS-WAHAI Consortium
- Australian National Health and Medical Research Council (NHMRC) [APP9000597]
- Australian Research Council (ARC) [FT200100243]
- Higher Committee for Education Development in Iraq (HCED)
- Australian Research Council [FT200100243]
- National Health and Medical Research Council
- European Union
- University of Western Australia
- Horizon 2020
- Higher Committee for Education Development in Iraq
- Australian Research Council [FT200100243] Funding Source: Australian Research Council
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Novel complexes of (NHC)Au(SCOR) were synthesised and characterised using spectroscopic techniques and X-ray diffraction. The results indicated that thiocarboxylate ligands have comparable electron donor ability with NHCs. The complexes were stable at room temperature in solid state but showed disproportionation reactions in solution. The thiocarboxylate ligand in (NHC)Au(SCOR) underwent rapid exchange with other thiocarboxylate or thiolate ligands. Furthermore, these complexes exhibited toxicity against cisplatin-resistant ovarian cancer cells.
Novel complexes of form (NHC)Au(SCOR) (NHC = N-heterocyclic carbene, SCOR- = thiocarboxylate ligand) were synthesised and characterised by spectroscopic techniques and X-ray diffraction studies. The results of NMR and X-ray studies indicated that thiocarboxylate ligands are comparable with NHCs in their electron donor ability. The complexes were stable at room temperature in the solid state but in solution underwent disproportionation reactions to form equilibria with [Au(NHC)(2)](+) and [Au(SCOR)(2)](-). In solution, the thiocarboxylate ligand in (NHC)Au(SCOR) underwent rapid exchange with other thiocarboxylate or thiolate ligands. The (NHC)Au(SCOR) complexes showed toxicity against cisplatin-resistant ovarian cancer cells (OVCAR-8), with IC50 < 10 mu M, in the range exhibited by cationic [Au(NHC)(2)](+) complexes well-known for their promising anticancer activity.
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