Journal
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Volume 106, Issue 5-6, Pages 1855-1878Publisher
SPRINGER
DOI: 10.1007/s00253-022-11821-5
Keywords
Microbial natural products; Antibiotics; Hypocholesterolemics; Anticancer drugs; Immunosuppressants; Antibiotic resistance
Categories
Funding
- DGAPA, PAPIIT [IN-205922]
- CONACYT [A-S1-9143]
- NUATEI program from Instituto de Investigaciones Biomedicas, UNAM
Ask authors/readers for more resources
Microorganisms are important producers of natural products that significantly improve human health. The discovery and study of antibiotics have played a crucial role in treating infectious diseases and introducing new molecules for treating various diseases. Smaller biotechnology companies and academic laboratories contribute to the development of novel antibiotics and secondary metabolites.
Microorganisms are remarkable producers of a wide diversity of natural products that significantly improve human health and well-being. Currently, these natural products comprise half of all the pharmaceuticals on the market. After the discovery of penicillin by Alexander Fleming 85 years ago, the search for and study of antibiotics began to gain relevance as drugs. Since then, antibiotics have played a valuable role in treating infectious diseases and have saved many human lives. New molecules with anticancer, hypocholesterolemic, and immunosuppressive activity have now been introduced to treat other relevant diseases. Smaller biotechnology companies and academic laboratories generate novel antibiotics and other secondary metabolites that big pharmaceutical companies no longer develop. The purpose of this review is to illustrate some of the recent developments and to show the potential that some modern technologies like metagenomics and genome mining offer for the discovery and development of new molecules, with different functions like therapeutic alternatives needed to overcome current severe problems, such as the SARS-CoV-2 pandemic, antibiotic resistance, and other emerging diseases.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available