Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 66, Issue 1, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01597-21
Keywords
Escherichia coli; antibiotic resistance; dissemination; insertion sequence; mobilization; tigecycline
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Funding
- Program for Innovative Research Team (in Science and Technology) at the University of Henan Province [18IRTSTHN020]
- German Federal Ministry of Education and Research (BMBF) [01KI1727D]
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The dissemination mechanism of the high-level tigecycline resistance gene tet(X4) in porcine Escherichia coli was investigated, and it was demonstrated that IS1A mediates the transposition of tet(X4) into the E. coli chromosome.
The dissemination mechanism of the high-level tigecycline resistance gene tet(X4) in porcine Escherichia coli was investigated. tet(X4) and other antimicrobial resistance genes were located on the plasmids p1919D3-1 and p1919D62-1 and flanked by two or three copies of IS1 family elements, which can form one to three translocatable units (TUs). Using a reduced transposition model, IS1A was experimentally demonstrated to mediate the transposition of tet(X4) from a suicide plasmid into the E. coli chromosome.
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