Journal
ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE
Volume 17, Issue -, Pages 121-139Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-pathol-052920-040318
Keywords
multiple sclerosis; immunology; autoimmune disease; pathomechanisms
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Multiple sclerosis is a chronic disease affecting the central nervous system, characterized by immune dysregulation and resulting in demyelination, neuronal damage, and degeneration. Genetic and environmental factors are believed to play a role in the onset and progression of this disease.
Multiple sclerosis (MS) is a chronic autoimmune, inflammatory, and neurodegenerative disease that affects the central nervous system (CNS). MS is characterized by immune dysregulation, which results in the infiltration of the CNS by immune cells, triggering demyelination, axonal damage, and neurodegeneration. Although the exact causes of MS are not fully understood, genetic and environmental factors are thought to control MS onset and progression. In this article, we review the main immunological mechanisms involved in MS pathogenesis.
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