Journal
ANNALS OF NEUROLOGY
Volume 91, Issue 5, Pages 676-681Publisher
WILEY
DOI: 10.1002/ana.26328
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Funding
- Swiss Academy of Medical Sciences [PHRT-103]
- Research Fund of the University of Basel
- Swiss National Science Foundation
- Biogen Switzerland
- Universitat Basel
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This study utilized single-cell mass cytometry to evaluate immune markers in multiple sclerosis patients treated with dimethyl fumarate. The research identified a negative correlation between CCR4-expressing T helper cells and relevant lymphopenia, suggesting CCR4-expressing T helper cells as a potential prognostic biomarker for lymphopenia development during DMF treatment.
Treatment with dimethyl fumarate (DMF) leads to lymphopenia and infectious complications in a subset of patients with multiple sclerosis (MS). Here, we aimed to reveal immune markers of DMF-associated lymphopenia. This prospective observational study longitudinally assessed 31 individuals with MS by single-cell mass cytometry before and after 12 and 48 weeks of DMF therapy. Employing a neural network-based representation learning approach, we identified a CCR4-expressing T helper cell population negatively associated with relevant lymphopenia. CCR4-expressing T helper cells represent a candidate prognostic biomarker for the development of relevant lymphopenia in patients undergoing DMF treatment. ANN NEUROL 2022
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