Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 60, Issue 52, Pages 27247-27252Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202111957
Keywords
kinetic resolution; palladium; Xiao-Phos; P-benzylation; P-stereogenic phosphines; sec-phosphine Oxides
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Funding
- NSFC [22031004, 21921003, 21772042, 21971066]
- China Postdoctoral Science Foundation [2021M691024]
- Science and Technology Commission of Shanghai Municipality [18JC1412300]
- Scientific research and innovation program of Shanghai Municipal Education Commission
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This study successfully achieved the kinetic resolution of rac-secondary phosphine oxides via enantioselective P-benzylation catalysis, delivering both tert- and sec-phosphine oxides in good yield and excellent enantiopurity. The synthetic utilities were further demonstrated by the facile preparation of valuable P-chiral compounds, precursors of bidentate ligands, and transition metal complexes.
P-stereogenic tert- and sec-phosphines have wide applications in asymmetric catalysis, materials, and pharmaceutical chemistry, however, their practical synthesis still constitutes a significant challenge. Herein, a successful kinetic resolution of rac-secondary phosphine oxides via the enantioselective P-benzylation process catalyzed by the palladium/Xiao-Phos was designed. Both tert- and sec-phosphine oxides were delivered in good yield and excellent enantiopurity (selectivity factor up to 226.1). The appealing synthetic utilities are further demonstrated by the facile preparation of several valuable P-chiral compounds, precursors of bidentate ligands, as well as transition metal complexes.
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