Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 61, Issue 13, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202115030
Keywords
Acoustic Mixing; Catalysis; Green Chemistry; Mechanochemistry; Pharmaceuticals
Categories
Funding
- NSERC [RGPIN-2017-06467]
- NSERC Discovery Accelerator [RGPAS 507837-17]
- Tier-1 Canada Research Chair Program
- NSERC PGS-D Scholarship
- NSERC CGS-D
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Resonant Acoustic Mixing (RAM) is a fast and operationally simple catalytic organic synthesis method that does not require bulk solvent or milling media. It allows for direct scaling up of reactions without significant changes in reaction conditions.
We demonstrate catalytic organic synthesis by Resonant Acoustic Mixing (RAM): a mechanochemical methodology that does not require bulk solvent or milling media. Using as model reactions ruthenium-catalyzed ring-closing metathesis and copper-catalyzed sulfonamide-isocyanate coupling, RAM mechanosynthesis is shown to be faster, operationally simpler than conventional ball-milling, while also providing the first example of a mechanochemical strategy for ruthenium-catalyzed ene-yne metathesis. Reactions by RAM are readily and directly scaled-up without any significant changes in reaction conditions, as shown by the straightforward 200-fold scaling-up of the synthesis of the antidiabetic drug Tolbutamide, from hundreds of milligrams directly to 30 grams.
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