Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 61, Issue 14, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202115954
Keywords
Alkenes; Cobalt; Electrocatalysis; Oxidation; Radicals
Categories
Funding
- NSFC [21971213, 22121001]
- Fundamental Research Funds for the Central Universities
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In this study, an electrocatalytic allylic C-H alkylation reaction with carbon nucleophiles was achieved using a readily available cobalt-salen complex as the catalyst. The mild conditions and unique electrocatalytic radical process allowed for excellent functional group tolerance and substrate compatibility.
The direct functionalization of allylic C-H bonds with nucleophiles minimizes pre-functionalization and converts inexpensive, abundantly available materials to value-added alkenyl-substituted products but remains challenging. Here we report an electrocatalytic allylic C-H alkylation reaction with carbon nucleophiles employing an easily available cobalt-salen complex as the molecular catalyst. These C(sp(3))-H/C(sp(3))-H crosscoupling reactions proceed through H-2 evolution and require no external chemical oxidants. Importantly, the mild conditions and unique electrocatalytic radical process ensure excellent functional group tolerance and substrate compatibility with both linear and branched terminal alkenes. The synthetic utility of the electrochemical method is highlighted by its scalability (up to 200 mmol scale) under low loading of electrolyte (down to 0.05 equiv) and its successful application in the late-stage functionalization of complex structures.
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