Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 61, Issue 5, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202110048
Keywords
antimicrobial; metallacycle; photodynamic inactivation; supramolecule
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Funding
- National Natural Science Foundation of China [22022404, 22074050, 21708012]
- Wuhan Scientific and Technological Projects [2019020701011441]
- CCNU
- MOE [CCNU20QN010]
- State Key Laboratory of Materials-Oriented Chemical Engineering [KL20-05]
- Opening Project of Guangxi Key Laboratory of High-Incidence-Tumor Prevention Treatment [GKE-KF202005]
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This study developed a supramolecular photosensitizer that can precisely monitor and effectively treat infected sites through the interaction between a metal cycle and host-guest chemistry. The photosensitizer showed potential for biomedical applications by tracking infection sites and performing efficient photodynamic inactivation in vivo.
Bacterial infection is one of the greatest threats to public health. In vivo real-time monitoring and effective treatment of infected sites through non-invasive techniques, remain a challenge. Herein, we designed a Pt-II metallacycle-based supramolecular photosensitizer through the host-guest interaction between a pillar[5]arene-modified metallacycle and 1-butyl-4-[4-(diphenylamino)styryl]pyridinium. Leveraging the aggregation-induced emission supramolecular photosensitizer, we improved fluorescence performance and antimicrobial photodynamic inactivation. In vivo studies revealed that it displayed precise fluorescence tracking of S. aureus-infected sites, and in situ performed image-guided efficient PDI of S. aureus without noticeable side effects. These results demonstrated that metallacycle combined with host-guest chemistry could provide a paradigm for the development of powerful photosensitizers for biomedicine.
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