Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 61, Issue 19, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202201390
Keywords
Betaine; Blood-Brain Barrier Crossing; Central Nervous System Diseases; Cylindrical Polymer Brushes; Fluorination
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Funding
- National Natural Science Foundation of China [52173129, 51422303, 51973092]
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This study reports an exciting finding that fluorination and betaine modification can significantly enhance the blood-brain barrier (BBB)-crossing ability of cylindrical polymer brushes (CPBs).
Blood-brain barrier (BBB)-crossing ability of drugs is of paramount importance for the treatments of central nervous system diseases. However, the known methods for drug transport across the BBB are generally complicated and inefficient, and exhibit serious side effects in some cases. Herein, we report an exciting finding that fluorination and betaine modification can significantly augment the BBB-crossing ability of cylindrical polymer brushes (CPBs), which was demonstrated by the comparison with the CPBs modified with alkyl and poly(ethylene glycol) chains, respectively. We surmise that fluorination enhances the BBB penetration of the CPBs by increasing the hydrophobicity and reducing the surface energy, and betaine medication achieves this function via a betaine transporter BGT1 expressed on brain capillaries. By means of an in vitro BBB model, we demonstrated that the CPBs penetrated the BBB through transendothelial transport. This work provides a novel strategy for enhancing the BBB-crossing ability of nanomaterials.
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