☆ 4.8 Article

Framework Nucleic Acid-Based Spatial-Confinement Amplifier for miRNA Imaging in Living Cells

ANALYTICAL CHEMISTRY (2022)

Related references

Note: Only part of the references are listed.

Article Chemistry, Multidisciplinary

Many Birds, One Stone: A Smart Nanodevice for Ratiometric Dual-Spectrum Assay of Intracellular MicroRNA and Multimodal Synergetic Cancer Therapy

Peng He et al.

Summary: The study presented an integrated smart nanodevice composed of Au@Cu2-xS@polydopamine nanoparticles and fuel DNA-conjugated tetrahedral DNA nanostructures for antitumor therapy and miRNA detection. Utilizing a SERS-FL dual-spectrum biosensor, the device achieved high detection sensitivity and low background signal for improved accuracy in diagnosing cancer cell miRNA.

ACS NANO (2021)

Add to Collection

Article Nanoscience & Nanotechnology

A One-Two-Three Multifunctional System for Enhanced Imaging and Detection of Intracellular MicroRNA and Chemogene Therapy

Xun Liu et al.

Summary: The study introduces a novel "one-two-three" system for enhanced imaging and detection of miRNA-21 in cancer cells, as well as chemogene therapy. The system features a miR-21-triggered endogenous substance-accelerated cyclic reaction, two signal switch modes, and three functions including enhanced imaging, detection, and comprehensive treatment.

ACS APPLIED MATERIALS & INTERFACES (2021)

Add to Collection

Article Chemistry, Analytical

Absolute Quantification of MicroRNAs in a Single Cell with Chemiluminescence Detection Based on Rolling Circle Amplification on a Microchip Platform

Shengyu Chen et al.

Summary: This study proposed an ultrasensitive chemiluminescence assay strategy for the absolute quantification of miRNAs in a single cell, based on rolling circle amplification on a microchip platform. The method was able to detect differences in miRNA content between cells and identify overexpression of miRNA-21 in HepG2 cells. The strategy offers advantages such as low cost, simplicity, short analysis time, good specificity, and lower false positive rates compared to traditional methods.

ANALYTICAL CHEMISTRY (2021)

Add to Collection

Article Chemistry, Analytical

CRISPR/Cas12a-Assisted Ligation-Initiated Loop-Mediated Isothermal Amplification (CAL-LAMP) for Highly Specific Detection of microRNAs

Mai Zhang et al.

Summary: A CRISPR/Cas12a-assisted sequence-specific detection method for LAMP products was developed to eliminate non-specific amplification effects. By designing target-specific stem-loop DNA probes, primer design for LAMP was greatly simplified, achieving sensitive detection of miRNAs with high specificity.

ANALYTICAL CHEMISTRY (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Imaging of Cancer Cells and Dictated Cytotoxicity Using Aptamer-Guided Hybridization Chain Reaction (HCR)-Generated G-Quadruplex Chains

Amily Fang-Ju Jou et al.

Summary: DNA nanotechnology provides a powerful tool for developing cancer theranostics, with autonomous surface-nucleolin-guided HCR leading to the formation of Zn-II PPIX-loaded G-quadruplex polymer chains for selective imaging and cytotoxicity towards TNBC. This method offers a promising platform for targeting TNBC, which has poor prognosis and high risk of recurrence.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Isothermal amplifications - a comprehensive review on current methods

Jorn Gloekler et al.

Summary: The introduction of nucleic acid amplification techniques, particularly isothermal amplification methods, has revolutionized the field of medical diagnostics by simplifying nucleic acid amplification and impacting the design of molecular diagnostics. Despite the advantages they bring, the heterogeneous issues and complexities surrounding different isothermal amplification methods make it challenging to identify the best approach.

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

A quantitative map of human primary microRNA processing sites

Kijun Kim et al.

Summary: Only 758 pri-miRNAs are confidently processed by DROSHA, while the majority may be non-canonical or false entries. Analyses of the DROSHA-dependent pri-miRNAs show key cis-elements for processing, and widespread alternative processing and unproductive cleavage events were observed.

MOLECULAR CELL (2021)

Add to Collection

Article Chemistry, Multidisciplinary

Framework nucleic acid programmed combinatorial delivery nanocarriers for parallel and multiplexed analysis

Yinghui Feng et al.

Summary: In this study, a nucleic acid programmed strategy was used to develop nanocarriers that can precisely package multiple cargos, allowing for multiplexed analysis and comparison between normal individuals and patients with prostate enlargement. Additionally, the nanocarriers were also able to image and distinguish between different cancer cells and normal cells.

CHEMICAL COMMUNICATIONS (2021)

Add to Collection

Review Chemistry, Multidisciplinary

DNA nanotechnology-empowered nanoscopic imaging of biomolecules

Fan Li et al.

Summary: Advancements in bioimaging technologies have led to the discovery of novel biological processes at the nanoscale, but there is a constant need for improvement in spatial and temporal resolution, multiplexity, and smart responsiveness. Self-assembled DNA nanostructures show promise in developing nanoscale probes and labels for high-performance bioimaging, overcoming bottlenecks in the field. However, challenges and opportunities still lie ahead in utilizing DNA nanotechnology in bioimaging strategies.

CHEMICAL SOCIETY REVIEWS (2021)

Add to Collection

Article Chemistry, Multidisciplinary

A minimal hybridization chain reaction (HCR) system using peptide nucleic acids

Ki Tae Kim et al.

Summary: The article introduces a minimal HCR system based on PNAs, which achieves rapid amplification using a system consisting of a 5-mer stem and 5-mer loop/toehold hairpins, suitable for detecting cancer biomarkers on live cells. The use of gamma-peg-modified PNA was found to be beneficial in this system.

CHEMICAL SCIENCE (2021)

Add to Collection

Review Chemistry, Multidisciplinary

Advances in multiplexed techniques for the detection and quantification of microRNAs

Thomas Jet et al.

Summary: MicroRNA detection is a crucial challenge in analytical chemistry, with the need for high sensitivity, specificity, robustness, and quantitative analysis. The ability to perform multiplexed detection of miRNA concentrations is important for recognizing disease signatures and new innovative detection methods have been developed to address this challenge.

CHEMICAL SOCIETY REVIEWS (2021)

Add to Collection

Article Chemistry, Analytical

Bioinspired Framework Nucleic Acid Capture Sensitively and Rapidly Resolving MicroRNAs Biomarkers in Living Cells

Fan Yang et al.

ANALYTICAL CHEMISTRY (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Environment-Recognizing DNA-Computation Circuits for the Intracellular Transport of Molecular Payloads for mRNA Imaging

Huihui Wang et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

Add to Collection

Letter Medicine, General & Internal

Positive RT-PCR Test Results in Patients Recovered From COVID-19

Lan Lan et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Add to Collection

Article Multidisciplinary Sciences

Size-selective molecular recognition based on a confined DNA molecular sieve using cavity-tunable framework nucleic acids

Xiaoyi Fu et al.

NATURE COMMUNICATIONS (2020)

Add to Collection

Article Chemistry, Multidisciplinary

Controlling the DNA Hybridization Chain Reaction

C. Adrian Figg et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

Add to Collection

Article Chemistry, Analytical

Efficient and Reliable MicroRNA Imaging in Living Cells via a FRET-Based Localized Hairpin-DNA Cascade Amplifier

Lu Liu et al.

ANALYTICAL CHEMISTRY (2019)

Add to Collection

Review Chemistry, Multidisciplinary

Applications of Catalytic Hairpin Assembly Reaction in Biosensing

Jumei Liu et al.

SMALL (2019)

Add to Collection

Article Chemistry, Analytical

Target-triggered programming of cascaded catalytic hairpin assemblies for enzyme-free and highly sensitive sensing of cytokines

Sujing Wang et al.

SENSORS AND ACTUATORS B-CHEMICAL (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Programming a split G-quadruplex in a DNA nanocage and its microRNA imaging in live cells

Yanyan Yu et al.

CHEMICAL COMMUNICATIONS (2019)

Add to Collection

Article Chemistry, Multidisciplinary

Valency-Controlled Framework Nucleic Acid Signal Amplifiers

Qi Liu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)

Add to Collection

Article Chemistry, Multidisciplinary

Genetically Encoded Catalytic Hairpin Assembly for Sensitive RNA Imaging in Live Cells

Aruni P. K. K. Karunanayake Mudiyanselage et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Add to Collection

Article Chemistry, Multidisciplinary

Multiplex microRNA imaging in living cells using DNA-capped-Au assembled hydrogels

Xiangdan Meng et al.

CHEMICAL SCIENCE (2018)

Add to Collection

Review Chemistry, Multidisciplinary

Concept and Development of Framework Nucleic Acids

Zhilei Ge et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2018)

Add to Collection

Article Chemistry, Multidisciplinary

A Responsive Nano String Light for Highly Efficient mRNA Imaging in Living Cells via Accelerated DNA Cascade Reaction

Kewei Ren et al.

ACS NANO (2018)

Add to Collection

Article Multidisciplinary Sciences

Biotechnological mass production of DNA origami

Florian Praetorius et al.

NATURE (2017)

Add to Collection

Review Chemistry, Multidisciplinary

The development of nanostructure assisted isothermal amplification in biosensors

Ruixue Duan et al.

CHEMICAL SOCIETY REVIEWS (2016)

Add to Collection

Article Chemistry, Multidisciplinary

Optimized DNA Nanosuitcases for Encapsulation and Conditional Release of siRNA

Katherine E. Bujold et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Multiplexed miRNA northern blots via hybridization chain reaction

Maayan Schwarzkopf et al.

NUCLEIC ACIDS RESEARCH (2016)

Add to Collection

Review Chemistry, Multidisciplinary

MicroRNA: Function, Detection, and Bioanalysis

Haifeng Dong et al.

CHEMICAL REVIEWS (2013)

Add to Collection

Article Cell Biology

miRNA profiling of cancer

Gianpiero Di Leva et al.

CURRENT OPINION IN GENETICS & DEVELOPMENT (2013)

Add to Collection

Review Biochemistry & Molecular Biology

Natural strategies for the spatial optimization of metabolism in synthetic biology

Christina M. Agapakis et al.

NATURE CHEMICAL BIOLOGY (2012)

Add to Collection

Review Genetics & Heredity

MicroRNA profiling: approaches and considerations

Colin C. Pritchard et al.

NATURE REVIEWS GENETICS (2012)

Add to Collection

Article Chemistry, Multidisciplinary

Self-Assembled Multivalent DNA Nanostructures for Noninvasive Intracellular Delivery of Immunostimulatory CpG Oligonucleotides

Jiang Li et al.

ACS NANO (2011)

Add to Collection

Review Oncology

Cell-free nucleic acids as biomarkers in cancer patients

Heidi Schwarzenbach et al.

NATURE REVIEWS CANCER (2011)

Add to Collection

Review Genetics & Heredity

The widespread regulation of microRNA biogenesis, function and decay

Jacek Krol et al.

NATURE REVIEWS GENETICS (2010)

Add to Collection

Review Biochemistry & Molecular Biology

MicroRNAs: Target Recognition and Regulatory Functions

David P. Bartel

CELL (2009)

Add to Collection

Review Biochemistry & Molecular Biology

Origins and Mechanisms of miRNAs and siRNAs

Richard W. Carthew et al.

CELL (2009)

Add to Collection

Article Chemistry, Multidisciplinary

Replication of a DNA microarray

HH Lin et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)

Add to Collection

Article Multidisciplinary Sciences

MicroRNA expression profiles classify human cancers

J Lu et al.

NATURE (2005)

Add to Collection

Article Multidisciplinary Sciences

The functions of animal microRNAs

V Ambros

NATURE (2004)

Add to Collection

Article Multidisciplinary Sciences

An oligonucleotide microchip for genome-wide microRNA profiling in human and mouse tissues

CG Liu et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Add to Collection

Article Multidisciplinary Sciences

Identification of novel genes coding for small expressed RNAs

M Lagos-Quintana et al.

SCIENCE (2001)

Add to Collection

© Peeref 2019-2024. All rights reserved.