Evidence That SARS-CoV-2 Induces Lung Cell Senescence: Potential Impact on COVID-19 Lung Disease

Article Cell Biology

Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages

Els Wauters et al.

Summary: Single-cell deep-immune profiling revealed that specific T cells in mild COVID-19 patients exhibit active expansion and function, while in critical COVID-19 they remain more naive. Furthermore, the monocyte-to-macrophage trajectories show enrichment of chronic hyperinflammatory monocytes and depletion of anti-inflammatory alveolar macrophages in critical COVID-19.

CELL RESEARCH (2021)

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Article Respiratory System

Pulmonary function and radiological features 4 months after COVID-19: first results from the national prospective observational Swiss COVID-19 lung study

Sabina A. Guler et al.

Summary: The Swiss COVID-19 lung study investigated pulmonary sequelae of COVID-19 in 113 survivors. Severe/critical COVID-19 was associated with significant functional and radiological abnormalities 4 months after infection, potentially due to small-airway and lung parenchymal disease. Systematic follow-up for survivors needs to be evaluated to optimize care for patients recovering from COVID-19.

EUROPEAN RESPIRATORY JOURNAL (2021)

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Article Multidisciplinary Sciences

Senolytics reduce coronavirus-related mortality in old mice

Christina D. Camell et al.

Summary: The research demonstrates that cellular senescence plays a critical role in pathogen infections, with aging mice experiencing increased senescence and inflammation after exposure to pathogens. Targeting cellular senescence can significantly reduce mortality and inflammatory markers.

SCIENCE (2021)

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Article Biochemistry & Molecular Biology