Journal
AMERICAN JOURNAL OF OPHTHALMOLOGY
Volume 238, Issue -, Pages 134-140Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ajo.2022.01.001
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The study aims to identify the impact of the Weiss ring on the measurement of mean and sectoral peripapillary retinal nerve fiber layer (pRNFL) thicknesses. It found that eyes with a Weiss ring showed thinner pRNFL thicknesses compared to normal eyes, especially in the inferior sector. This could be a significant confounding factor in the analysis of pRNFL changes, particularly in patients with glaucoma.
PURPOSE: To identify how the Weiss ring affects the measurement of mean and sectoral peripapillary retinal nerve fiber layer (pRNFL) thicknesses. DESIGN: Retrospective, cross-sectional study. METHODS: Subjects were divided into two groups: controls (control group) and subjects in which a Weiss ring was visible on optical coherence tomography fundus images (WR group). Mean and sectoral pRNFL thicknesses were compared between the two groups. RESULTS: A total of 205 eyes were enrolled: 131 eyes in the control group and 74 eyes in the WR group. The mean pRNFL thicknesses of the control group and WR group were 97.2 +/- 6.7 mu m and 94.6 +/- 10.8 mu m, respectively (P = .042). In sectoral thickness, the inferior sector of the WR group was 112.1 +/- 23.2 mu m, which was significantly thinner than that of the control group (125.5 +/- 13.3 mu m; P < .001). The Weiss ring was located in 10 eyes (13.5%) in the superior sector, 7 eyes (9.5%) in the temporal sector, 40 eyes (54.1%) in the inferior sector, and 17 eyes (23.0%) in the nasal sector. In analyses of reproducibility, the coefficient of variation and intra-class coefficient of the inferior sector measurement were 10.90% and 0.409, respectively, indicating low reliability of the measurement. CONCLUSIONS: Eyes with a Weiss ring showed thinner mean and inferior pRNFL thicknesses than normal controls, which would be a measurement error caused by the Weiss ring. This could be a major confounding factor for analyses of pRNFL changes, especially in glaucoma patients. (c) 2022 Elsevier Inc. All rights reserved.
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