ICU-acquired central line-associated bloodstream infection and its associated factors in Oman

Background: Despite the extensive use of central lines for ICU patients in Oman, no studies have been con-ducted among adult ICU patients to assess the prevalence, and predictors of CLABSIs. Aim: To estimate the prevalence of ICU-acquired CLABSIs, identify the most common causative microorgan-isms, and define possible related risk factors associated with ICU-acquired CLABSIs among adult ICU patients in Oman.Method: A retrospective case-control design was used to screen electronic medical records of for all adult ICU patients admitted over 2 years (2018-2019) in 2 tertiary hospitals in Oman. The CDC definition of CLABSIs was used to allocate a cases group (n = 58), anda randomly selected controls group (n = 174).Results: The prevalence of ICU-acquired CLABSIs was 8.9 and 8.31 per 1,000 catheter days for the years 2018 and 2019 respectively. The most common isolated microorganisms were gram-positive bacteria (46.6%). The risk factors for ICU-acquired CLABSIs are: heart failure (Odds Ratio [OR] = 11.67, P < .001), female gender (OR = 0.352, P = .035), presence of other infections (OR = 3.4, P = .009), tracheostomy (OR = 5.34, P = .004), and Total Parenteral Nutrition (OR = 3.469, P = .020).Conclusions: The prevalence of ICU-acquired CLABSIs in developing countries like Oman is higher than most of developed countries. The current study provides baseline data that can be used as a reference for future national studies and help in building strategies to prevent and control ICU-acquired CLABSIs.(c) 2022 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

Automated summary

This study investigated the prevalence, causative microorganisms, and associated risk factors of ICU-acquired central line-associated bloodstream infections (CLABSIs) among adult ICU patients in Oman. The results showed a higher prevalence of ICU-acquired CLABSIs in Oman compared to developed countries, with gram-positive bacteria being the most common isolates. Risk factors for ICU-acquired CLABSIs included heart failure, female gender, presence of other infections, tracheostomy, and Total Parenteral Nutrition.