Immune Response Induced by SARS-CoV-2 Vaccines in Patients With Inflammatory Bowel Disease Under Biologic Therapy

Summary: This study evaluated the humoral immunogenicity of mRNA COVID-19 vaccines in patients with IBD and healthy controls. The results showed that almost all IBD patients and healthy controls developed an antibody response after vaccination. However, IBD patients had lower antibody concentrations compared to the healthy controls, and those who received the Moderna vaccine had higher antibody concentrations. Patients on immune-modifying therapy had lower antibody concentrations.