Journal
AMERICAN JOURNAL OF EPIDEMIOLOGY
Volume 191, Issue 5, Pages 825-833Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/aje/kwac007
Keywords
cohort; diet; epidemiology; glioblastoma; glioma; pesticide; pesticide residue
Categories
Funding
- National Institutes of Health [PO1 CA87969, U01 CA167552, UM1 CA186107, U01 CA176726, UM1 CA167552, R24ES028521, F30 CA235791]
- American Heart Association [34106]
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This study investigated the association between intake of pesticide residues from fruits and vegetables and glioma. The results showed a significant association between intake of high-residue fruits and vegetables and glioma in one cohort, but not in the other cohorts.
We aimed to determine whether intake of pesticide residues from fruits and vegetables was associated with glioma. Within 3 prospective cohorts from 1998-2016-the Nurses' Health Study (NHS), Nurses' Health Study II (NHSII), and Health Professionals Follow-up Study-we computed multivariable-adjusted hazard ratios (MVHRs) and 95% confidence intervals (CI) for glioma by quintiles of intake of low- and high-pesticide-residue fruits and vegetables using Cox proportional hazards regression. Fruits and vegetables were categorized as high or low residue using a validated method based on pesticide surveillance data. We confirmed 275 glioma cases across 2,745,862 person-years. A significant association was observed between intake of high-residue fruits and vegetables and glioma in NHS (MVHR = 2.99, 95% CI: 1.38, 6.44 comparing highest with lowest quintile, P for trend = 0.02). This was not identified in NHSII (MVHR = 0.52, 95% CI: 0.19, 1.45, P for trend = 0.20) or Health Professionals Follow-up Study (MVHR = 1.01, 95% CI: 0.42, 2.45, P for trend = 0.39). No significant associations were observed by intake of low-residue fruits and vegetables; overall intake was not significantly associated with glioma in any cohort. We found no evidence for an inverse relationship of fruit and vegetable intake with glioma. Although limited in power, this study suggests a possible association between fruit-and-vegetable pesticide residue intake and risk of glioma that merits further study.
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