Journal
ALZHEIMERS & DEMENTIA
Volume 18, Issue 7, Pages 1408-1423Publisher
WILEY
DOI: 10.1002/alz.12485
Keywords
definition; frontotemporal dementia; frontotemporal lobar degeneration; mild cognitive and; or behavioral and; or motor impairment; mild cognitive impairment; preclinical; presymptomatic; prodromal
Categories
Funding
- JPND grant GENFI-prox
- Alzheimer's Society, UK [AS-JF-19a-004-517]
- UK Dementia Research Institute - DRI Ltd
- UK Medical Research Council
- Alzheimer's Society
- Alzheimer's Research UK
- MRC Clinician Scientist Fellowship [MR/M008525/1]
- NIHR Rare Disease Translational Research Collaboration [BRC149/NS/MH]
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The presymptomatic stages of frontotemporal dementia (FTD) have not been clearly defined, indicating a need for a consensus lexicon to comprehensively describe the stages that anticipate dementia and to formulate a better strategy for characterizing these disease stages.
The presymptomatic stages of frontotemporal dementia (FTD) are still poorly defined and encompass a long accrual of progressive biological (preclinical) and then clinical (prodromal) changes, antedating the onset of dementia. The heterogeneity of clinical presentations and the different neuropathological phenotypes have prevented a prior clear description of either preclinical or prodromal FTD. Recent advances in therapeutic approaches, at least in monogenic disease, demand a proper definition of these predementia stages. It has become clear that a consensus lexicon is needed to comprehensively describe the stages that anticipate dementia. The goal of the present work is to review existing literature on the preclinical and prodromal phases of FTD, providing recommendations to address the unmet questions, therefore laying out a strategy for operationalizing and better characterizing these presymptomatic disease stages.
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