Journal
ALZHEIMERS & DEMENTIA
Volume 18, Issue 7, Pages 1424-1437Publisher
WILEY
DOI: 10.1002/alz.12486
Keywords
diet; exposome; individualized prevention; nutrition; precision medicine; precision nutrition; prevention; risk factors in epidemiology
Categories
Funding
- Alzheimer's Association as part of the ISTAART Professional Interest Area on Nutrition and Metabolic disorders
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Personalized nutrition may offer advantages in preventing dementia by incorporating individuals' dietary exposure history and biological characteristics to shape health more effectively. Further research from observational epidemiology to basic science is needed to achieve better prevention outcomes.
The role of nutrition has been investigated for decades under the assumption of one-size-fits-all. Yet there is heterogeneity in metabolic and neurobiological responses to diet. Thus a more personalized approach may better fit biological reality and have increased efficacy to prevent dementia. Personalized nutrition builds on the food exposome, defined as the history of diet-related exposures over the lifetime, and on its interactions with the genome and other biological characteristics (eg, metabolism, the microbiome) to shape health. We review current advances of personalized nutrition in dementia research. We discuss key questions, success milestones, and future roadmap from observational epidemiology to clinical studies through basic science. A personalized nutrition approach based on the best prescription for the most appropriate target population in the most relevant time-window has the potential to strengthen dementia-prevention efforts.
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