Related references
Note: Only part of the references are listed.
Article
Allergy
Maria Anna Bruusgaard-Mouritsen et al.
Summary: This study evaluated the reactivity of different molecular weight PEGs in skin prick tests and investigated cross-sensitization patterns in PEG allergy. The results showed that skin test reactivity to PEG can decrease over time, but titrated SPT with increasing concentrations of PEG 20,000 can be diagnostic.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Editorial Material
Allergy
Beatriz Cabanillas et al.
Article
Allergy
Milena Sokolowska et al.
Summary: The discussion focuses on the management and prevention of vaccine allergic reactions, providing a detailed algorithm for diagnosing and treating severe allergic reactions, along with recommendations for appropriate medications and equipment. A workup for identifying potential allergenic components in vaccines is proposed, along with a suggested international collaborative approach to reduce the risk of allergic reactions to COVID-19 vaccines.
Review
Allergy
Ludger Klimek et al.
Summary: Following the emergency use authorization of the mRNA-1273 vaccine, two mRNA vaccines have been used to prevent COVID-19, but reports of allergic reactions have surfaced in the UK, Canada, and the US. The culprit may be the PEG-2000 contained in both vaccines as a potential trigger.
Letter
Allergy
Priya Sellaturay et al.
CLINICAL AND EXPERIMENTAL ALLERGY
(2021)
Article
Allergy
Kimberly A. Risma et al.
Summary: The COVID-19 pandemic has led to the rapid production of messenger RNA vaccines packaged in lipid nanoparticles, resulting in unexpectedly severe allergic reactions. Various factors have been considered as possible contributors to these reactions, including nucleic acid activation of the contact system and preexisting antibody recognition of polyethylene glycol on the nanoparticle surface. Further research and clinical trials are needed to address concerns and determine the applicability of testing methods in predicting and understanding vaccine-related allergic reactions.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Alexander Troelnikov et al.
Summary: Patients with a history of PEG allergy showed positive skin test results after receiving the BNT162b2 vaccine, while traditional PEG skin testing yielded negative results for 2 out of 3 patients. One patient exhibited cross-reactivity to PEG and polysorbate, leading to co-sensitization to both the BNT162b2 and AZD1222 vaccines.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Allergy
Matthew Greenhawt et al.
Summary: This study involved an international multidisciplinary group of experts to systematically investigate the incidence of anaphylaxis after SARS-CoV-2 vaccination and the accuracy of allergy testing tools. The research found a low incidence of anaphylaxis after SARS-CoV-2 vaccination and low sensitivity of polyethylene glycol skin testing, but high specificity. Recommendations were made for vaccination for individuals without a history of severe allergic reactions and shared decision-making with an allergy specialist for those with a history of severe allergic reactions. Further research is recommended to clarify the utility of testing in individuals potentially allergic to SARS-CoV-2 vaccines or their excipients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Medicine, General & Internal
Christopher Michael Warren et al.
Summary: This study analyzed 22 patients with suspected allergic reactions to mRNA COVID-19 vaccines, indicating a potential non-IgE mediated immune response to PEG in most individuals. Women and those with a history of allergic reactions may have an elevated risk of mRNA vaccine allergy.
Review
Allergy
Daniel Elieh Ali Komi et al.
