Journal
ALLERGY
Volume 77, Issue 2, Pages 681-685Publisher
WILEY
DOI: 10.1111/all.15145
Keywords
ALI culture; allergic; asthma; asthma control test score; asthma exacerbation; CRTH2; epithelial tight junction; PGD2; Treg cells; Tregs dysfunction
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Funding
- Phramongkutklao Hospital and Phramongkutklao College of Medicine foundation Scholarship
- Christine Kuhne-Center for Allergy Research and Education (CK-CARE)
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The frequency of CRTH2(+)Tregs is higher in patients with asthma, especially allergic phenotype, compared to healthy controls, and shows a negative correlation with ACT scores and PEFR. CRTH2(+)Tregs increase during exacerbation and decrease after asthma control. In vitro investigations demonstrate that Tregs of allergic patients with asthma display Th2-biased character.
The frequency of CRTH2(+)Tregs in patients with asthma, especially allergic phenotype is higher compared to healthy controls and shows a negative correlation with ACT scores and PEFR. CRTH2(+)Tregs increase during exacerbation and decrease after asthma control. In vitro investigations demonstrate that Tregs of allergic patients with asthma display Th2-biased character. Abbreviation: CRTH2, chemoattractant receptor-homologous molecule expressed on Th2 cells; Tregs, regulatory T cells; ACT, asthma control test; PEFR, peak expiratory flow rate.
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