Journal
AICHE JOURNAL
Volume 67, Issue 12, Pages -Publisher
WILEY
DOI: 10.1002/aic.17470
Keywords
biomaterials; biomedical engineering; controlled drug delivery; release; emulsion electrospinning; fibers
Categories
Funding
- National Institute of General Medical Sciences [GM008359]
- Howard Hughes Medical Institute [GT13590]
- University of Kansas
Ask authors/readers for more resources
Emulsion electrospinning was used to develop porous scaffolds for controlled drug delivery in tissue engineering, with the study showing the significant impact of drug interactions with emulsion chemistry on drug loading efficiency and release rates. The results highlighted the need to independently control intermolecular interactions and drug phase solubility in designing fibers for tunable drug delivery systems.
Emulsion electrospinning provides a tunable system for the development of porous scaffolds for controlled, localized drug delivery in tissue engineering applications. This study aimed to elucidate the role of model drug interactions with emulsion chemistry on loading and release rates from fibers with controlled fiber diameter and fiber volume fraction. Nile Red and Rhodamine B were used as model drugs and encapsulation efficiency and release rates were determined from poly(caprolactone) (PCL) electrospun fibers spun either with no surfactant (Span 80), surfactant, or water-in-oil emulsions. Drug loading efficiency and release rates were modulated by both surfactant and aqueous internal phase in the emulsions as a function of drug molecule hydrophobicity. Overall, these results demonstrate the role of intermolecular interactions and drug phase solubility on the release from emulsion electrospun fibers and highlight the need to independently control these parameters when designing fibers for use as tunable drug delivery systems.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available