Journal
AGING CELL
Volume 21, Issue 2, Pages -Publisher
WILEY
DOI: 10.1111/acel.13550
Keywords
ageing; bioengineered tissue; human; in vitro; molecular biology of aging; skin
Categories
Funding
- Biotechnology and Biological Sciences Research Council [BB/K019260/1, BB/M011186/1]
- BBSRC [BB/K019260/1] Funding Source: UKRI
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Human skin ageing is a complex process influenced by genetic and environmental factors. The development of bioengineered ageing skin models has advanced our understanding of the molecular mechanisms of skin ageing and provided a platform for testing active ingredients and formulations.
Human skin ageing is a complex and heterogeneous process, which is influenced by genetically determined intrinsic factors and accelerated by cumulative exposure to extrinsic stressors. In the current world ageing demographic, there is a requirement for a bioengineered ageing skin model, to further the understanding of the intricate molecular mechanisms of skin ageing, and provide a distinct and biologically relevant platform for testing actives and formulations. There have been many recent advances in the development of skin models that recapitulate aspects of the ageing phenotype in vitro. This review encompasses the features of skin ageing, the molecular mechanisms that drive the ageing phenotype, and tissue engineering strategies that have been utilised to bioengineer ageing skin in vitro.
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