4.7 Article

Microglial cathepsin E plays a role in neuroinflammation and amyloid β production in Alzheimer's disease

Related references

Note: Only part of the references are listed.
Review Cell Biology

The microglial lysosomal system in Alzheimer's disease: Guardian against proteinopathy

Zoe P. Van Acker et al.

Summary: Microglia, the brain-resident immune cells, are crucial for maintaining brain homeostasis and can adapt to specific activation states based on signals from the microenvironment. The activated response microglia (ARMs) phenotype plays a significant role in neurodegenerative diseases, with characteristics such as increased metabolism, phagocytosis rate, and secretion of neuroprotective factors. This phenotype is believed to be an adaptive response to restore homeostasis in the presence of risk factors and genetic variations associated with diseases like Alzheimer's.

AGEING RESEARCH REVIEWS (2021)

Article Chemistry, Multidisciplinary

Single Molecule Assay for Ultrasensitive Detection of Cathepsin B in Human Blood

Bharani Thangavelu et al.

Summary: Cathepsin B, a lysosomal cysteine protease, plays a crucial role in protein degradation and is used as a biomarker for diagnostic purposes. The digital enzyme-linked immunosorbent assay (ELISA) developed for differential detection of catB in small blood samples offers higher sensitivity and reduced variance compared to traditional tests.

ACS OMEGA (2021)

Review Cell Biology

5-Lipoxygenase as an emerging target against age-related brain disorders

Mengdie Yan et al.

Summary: Neuroinflammation is a common feature of age-related brain disorders such as Alzheimer's disease, Parkinson's disease, and cerebral ischemia. The proinflammatory enzyme 5-lipoxygenase (5-LOX) plays a crucial role in modulating inflammation by generating leukotrienes, and its abnormal activation and excessive production have been detected in the development of age-related brain pathology. Inhibition of 5-LOX activation may represent a promising therapeutic strategy for AD, PD, and cerebral ischemia.

AGEING RESEARCH REVIEWS (2021)

Article Biochemistry & Molecular Biology

Grassystatin-derived peptides selectively inhibit cathepsin E and have low affinity to cathepsin D

Sophie Stotz et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Review Biochemistry & Molecular Biology

Cathepsin regulation on microglial function

Hiroshi Nakanishi

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS (2020)

Review Biochemistry & Molecular Biology

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

Justin M. Long et al.

Article Multidisciplinary Sciences

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model

Elizabeth Spangenberg et al.

NATURE COMMUNICATIONS (2019)

Article Neurosciences

PU.1 regulates Alzheimer's disease-associated genes in primary human microglia

Justin Rustenhoven et al.

MOLECULAR NEURODEGENERATION (2018)

Article Multidisciplinary Sciences

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

Tyler J. Bussian et al.

NATURE (2018)

Article Immunology

Differential expression of Cathepsin E in transthyretin amyloidosis: from neuropathology to the immune system

Nadia Pereira Goncalves et al.

JOURNAL OF NEUROINFLAMMATION (2017)

Article Multidisciplinary Sciences

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer's disease

Carmen Venegas et al.

NATURE (2017)

Review Biochemistry & Molecular Biology

APP mouse models for Alzheimer's disease preclinical studies

Hiroki Sasaguri et al.

EMBO JOURNAL (2017)

Article Biochemistry & Molecular Biology

A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease

Hadas Keren-Shaul et al.

Review Cell Biology

Lysosomal cathepsins and their regulation in aging and neurodegeneration

Veronika Stoka et al.

AGEING RESEARCH REVIEWS (2016)

Review Chemistry, Medicinal

The Role of Cathepsin D in the Pathogenesis of Human Neurodegenerative Disorders

Chiara Vidoni et al.

MEDICINAL RESEARCH REVIEWS (2016)

Article Cell Biology

TRAIL activates JNK and NF-κB through RIP1-dependent and -independent pathways

Laiqun Zhang et al.

CELLULAR SIGNALLING (2015)

Review Clinical Neurology

Neuroinflammation in Alzheimer's disease

Michael T. Heneka et al.

LANCET NEUROLOGY (2015)

Article Neurosciences

Single App knock-in mouse models of Alzheimer's disease

Takashi Saito et al.

NATURE NEUROSCIENCE (2014)

Article Biochemistry & Molecular Biology

Role of the transcription factor Sp1 in regulating the expression of the murine cathepsin E gene

Kuniaki Okamoto et al.

JOURNAL OF BIOCHEMISTRY (2012)

Article Chemistry, Medicinal

Grassystatins A-C from Marine Cyanobacteria, Potent Cathepsin E Inhibitors That Reduce Antigen Presentation

Jason C. Kwan et al.

JOURNAL OF MEDICINAL CHEMISTRY (2009)

Article Neurosciences

Microglial dysfunction and defective β-amyloid clearance pathways in aging Alzheimer's disease mice

Suzanne E. Hickman et al.

JOURNAL OF NEUROSCIENCE (2008)

Article Biochemical Research Methods

Tricine-SDS-PAGE

Hermann Schaegger

NATURE PROTOCOLS (2006)

Review Biochemistry & Molecular Biology

Neutralization of TRAIL death pathway protects human neurional cell line from beta-amyloid toxicity

G Cantarella et al.

CELL DEATH AND DIFFERENTIATION (2003)

Article Biochemistry & Molecular Biology

Regulation of human and mouse procathepsin E gene expression

M Cook et al.

EUROPEAN JOURNAL OF BIOCHEMISTRY (2001)