Journal
AGEING RESEARCH REVIEWS
Volume 72, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.arr.2021.101500
Keywords
Methionine restriction; Methionine supplementation; FGF-21; AMPK; mTOR; Aging; Insulin sensitivity
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Funding
- Central University of Punjab, Bathinda under the RSM grant-2020 [GP-25]
- Council of Scientific & Industrial Research (CSIR), India
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Methionine plays a vital role in cellular processes, with both restriction and supplementation showing potential benefits, but dosage is crucial. Restriction can extend lifespan, while excessive intake may lead to adverse effects.
Methionine is one of the essential amino acids and plays a vital role in various cellular processes. Reports advocate that methionine restriction and supplementation provide promising outcomes, and its regulation is critical for maintaining a healthy life. Dietary methionine restriction in houseflies and rodents has been proven to extend lifespan. Contrary to these findings, long-term dietary restriction of methionine leads to adverse events such as bone-related disorders, stunted growth, and hyperhomocysteinemia. Conversely, dietary supplementation of methionine improves hepatic steatosis, insulin resistance, inflammation, fibrosis, and bone health. However, a high level of methionine intake shows adverse effects such as hyperhomocysteinemia, reduced body weight, and increased cholesterol levels. Therefore, dietary methionine in a safe dose could have medicinal values. Hence, this review is aimed to provide a snapshot of the dietary role and regulation of methionine in the modulation of health and age-related diseases.
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